Biopharmaceutical choice justification of basis for dermatological ointment

Authors

DOI:

https://doi.org/10.24959/ubphj.18.190

Keywords:

biopharmaceutical studies, extemporally ointments, emulsion ointment bases

Abstract

Topicality. In the extemporal ointments manufactured in Ukraine, vaseline or a mixture of lanolin with vaseline are used as a base. The prospect of the extemporal prescription encourages the improvement of the outdated foundations, which will allow a more complete release of the active ingredients and minimize their negative impact on the physiological state of the skin.

Aim. To study nature and composition influence of bases on the dynamics of medicinal substances release and the antimicrobial activity of an ointment with boric and salicylic acid.

Materials and methods. The dynamics of medicinal substances release was studied by equilibrium dialysis through a semipermeable membrane of the ointment with 5 % boric acid and 20 % salicylic acid, which are made on the different bases. The antimicrobial activity of ointment samples was studied in vitro conditions by the diffusion into agar standard in microbiological practice in the modification of wells.

Results and discussion. A comparative analysis of the dynamics of medicinal substances release and antimicrobial activity of the samples showed a dependence on the nature and composition of the bases. The most degree of release of medicinal substances and antimicrobial activity was detected in samples on an emulsion basis compared with fat.

Conclusions. The results are indicate obtained the dependence of dynamics of medicinal substances release and antibacterial activity on the nature and composition of the base and allow us to recommend the emulsion bases for salicylic and boric ointments.

Author Biographies

E. Zuikina, National University of Pharmacy

PhD Student of Pharmacy Technology Department

N. Polovko, National University of Pharmacy

professor, Doctor of Pharmaceutical Sciences, Department of Pharmacy Technology of Medicine

L. Silayva, National University of Pharmacy

PhD, associate professor Microbiology Department 

T. Kovalova, National University of Pharmacy

PhD, associate professor of Pharmacy Technology Department 

References

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Published

2018-12-05

Issue

Section

Biopharmaceutical research