Study of the relations between the main BAS groups content in Leonurus cardiaca tincture and its psychotropic activity
DOI:
https://doi.org/10.24959/ubphj.18.199Keywords:
Motherwort, herb, tincture, psychotropic activityAbstract
Topicality. Motherwort herb tincture is one of the most popular herbal remedies of sedative action. The disadvantage of this medicines is chemical composition volatility, and as a consequence, pharmacodynamics. Therefore, it is advisable to investigate BAS groups of Motherwort herb tincture having the greatest effect on its psychotropic activity and in the future to standardize the medicines precisely with their content.
Aim. To determine the relationship between the main BAS groups content in Motherwort herb (Leonurus cardiaca) and its psychotropic activity in order to establish the parameters of this medicine standardization.
Materials and methods. The object of the study was Motherwort herb tincture (series 15.04.16, produced at LTD “Pharmaceutical factory”, Zhytomyr region., Stanishevka v.) and the main BAS groups complexes of isolated from. Determination of hydroxycinnamic derivatives acid, flavonoids and the sum of phenolic compounds, iridoids were carried out by spectrophotometric method and HPLC method. The psychotropic activity of the research objects were studied in the open field test in the NUPh Central Research Laboratory.
Results and discussion. As a result of the chemical analysis of the tincture and obtained BAS complexes, 2 flavonoids (routine and catechin), 3 hydroxycinnamic acids (chlorogenic, coffeic and rosemarinic), 2 iridoids were identified and their quantitative contents were determined. It was established that Motherwort herb tincture and its components significantly decreases the sum of all types of psychotropic activity, mainly due to the reduction of motor activity. At the same time, it also shows a tendency to decrease the approximate research activity, indicating its sedative effect. The largest sedative activity in the smallest doses a complex of iridoids demonstrated. It should be taken into the account when this medicine is standardized.
Conclusions. The study of qualitative composition and quantitative content of the main BAS groups (flavonoids, hydroxycinnamic acids, iridoids) in the Motherwort herb tincture and dry extracts based on it. The most sedative activity was shown by substances rich in iridoids, indicating the appropriateness of standardizing Motherwort herb tincture on the content of this particular BAS group.
References
Koshovyi, O. M., Romanenko, Ye. A., Komissarenko, A. M. (2016). The study of the phenolic composition of the dry extract of motherwort herb and its psychotropic activity. American Journal of Science and Technologies, “Princeton University Press”, 1 (21), 1055–1059.
Romanenko, Y., Koshovyi, O., Komissarenko, A., Golembiovska, O., & Gladyish, Y. (2018). The study of the chemical composition of the components of the motherwort herb. Vìsnik farmacìï, 3 (95), 34–38. http://doi.org/10.24959/nphj.18.2222
Derzhavne pidpryiemstvo “Ukrainskyi naukovyi ekspertnyi farmakopeinyi tsentr yakosti likarskykh zasobiv”. (2015). Derzhavna farmakopeia Ukrainy. (Vols 1–3, Vol. 1). (2–e ed.) Kharkiv, 1128.
Kosman, V. M., Pozharitckaia, O. N., Shikova, A. N., Makarov, V. G. (2002). Khimiko-farmatcevticheskii zhurnal, 36 (2), 43–45.
Osmachko, A. P. (2017). Fitokhimichne doslidzhennia veroniky dovholystoi ta veroniky shyrokolystoi, ekstraktiv na yikh osnovi ta yikh standartyzatsiia. Candidate’s thesis. Kharkiv: NPaU, 320.
Koshovyi, O. M., Komisarenko, A. M., Kovalova, A. M., Maloshtan, L. M., Mudryk, I. M. (2005). Pharmacom, 2/3, 151–
Kovalova, A. M., Heorhiievskyi, H. V., Kovalov, V. M., Komisarenko, A. M., Tymchenko, M. M. (2002). Pharmacom, 2, 92–97.
Golembiovska, O. I. (2014). Simultaneous determination of flavonoids and phenolic acids in different parts of Prunella vulgaris L. by high-performance liquid chromatography with photodiode array detection. Int. J. Pharmacog. Phytochem., 29 (1), 1248–1255.
Stefanov, O. (2001). Doklinichni doslidzhennia likarskykh zasobiv. Kyiv: “Avitsena”, 528.
Deyko, R. D., Strygol, S. Yu, Prusakov, A. N., Kolobov, O. O. (2015). Ukraïns’kij bìofarmacevtičnij žurnal, № 1 (36), 14–20.
European convention for the protection of vertebrate animals used for experimental and other scientific purposes. (1986). Council of Europe, Strasbourg, 53.
Dmitrievskaya, I. D., Danilov, S. A., Dmitrievskiy, D. I., Shtryhol, S. Yu., Komisarenko, A. M., Hudzenko, O. P. (2011). Ukrainskyi zhurnal klinicheskoy i laboratornoy medicine, 6 (2), 4–8.
Downloads
Published
Issue
Section
License
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
