The experimental study of anti-inflammatory activity of extracts from the plants of Iridaceae family




anti-inflammatory activity, dry extracts, Iridaceae, carrageenan edema


Topicality. The presence of the inflammatory process as a pathological basis for the development of many diseases has led to the search for new herbal medicines for the study of anti-inflammatory activity of the dry extracts from the plant raw material of Iridaceae.

Aim. To study the anti-inflammatory properties of new dry extracts from different types of plants raw materials of Iridaceae family in certain doses. Model of carregenic edema in rats used. To make a comparison according to this type of pharmacological activity.

Materials and methods. The objects of the study were the dry hydrophilic extracts of Iris hungarica leaves, stigmas and corms of Crocus sativus, Gladiolus hybrida hort. Leaves and Juno bucharia leaves. It is known that in pathogenesis of carrageenan inflammation in 1.5-5.5 hours after the introduction of flogogenic, the leading role is played by the prostaglandin, which allows us to conclude  the studied extracts effects  on the cyclooxygenase system. The anti-inflammatory activity of extracts was examined at a dose of 25 mg/kg.

Results and discussion. Among the studied dry extracts in a dose of 25 mg/kg, the carrageenal edema was reduced by a factor of 1.42 for 3 hours (anti-inflammatory activity was 81.38 %). Preliminary introduction the Crocus sativus stigmas and corms extracts to the animal body also showed the presence of perverted anti-inflammatory activity (73.24 and 78.61 %, respectively). In the range of  presented extracts in a dose of 25 mg/kg, according to the anti-inflammatory effect, extracts can be arranged in the following order: Juno > Crocus corm > Crocus stigma > Iris leaves. Gladiolus extract showed the anti-inflammatory activity in chosen dose below 50 %.

Conclusions. The plant extracts in a dose of 25 mg/kg showed varying degrees of anti-exudative activity and the ability to suppress synthesis of prostaglandins.

Author Biographies

O. Shatalova, National University of Pharmacy

Candidate of Pharmaceutical Sciences, Associate Professor at the Department of Physiology and Anatomy

O. Mykhailenko, National University of Pharmacy

Candidate of Pharmaceutical Sciences, Assistant at the department of Botany


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Pharmacology and biochemistry