Analytical review of Prochlorperazine side effects and acute poisonings




prochlorperazine, poisoning, side effects, chemical-toxicological analysis


Topicality. The article presents the analytical review data of the toxicological effects of prochlorperazine usage. Prochlorperazine is a sufficiently used drug with neuroleptic and antiemetic activity. It’s produced as a generic drug in many countries in the world in the form of tablets, suppositories and injection.

Aim. To conduct an analytical review of prochlorperazine side effects and acute poisonings of controlled and uncontrolled usage.

Results and discussion. According to information sources, in the period from 2010 till 2016 year were registered 258 cases of prochlorperazine acute poisoning in the world. The main causes of acute prochlorperazine poisoning noted with side effects of the treatment of it in therapeutic doses. Prochlorperazine is incompatible with drugs that suppress the central nervous system and increases the risk of neonatal complications if pregnant women use. Approximately 10 % of prochlorperazine numbers of acute poisonings are lethal cases of overdose. They are often due to suicide drug overdose. The drugs that were used simultaneously with prochlorperazine for suicide were defined: clonazepam, lorazepam, aprazolam, ibuprofen, naproxen, diazepam, seroquel, depacote, etc.

Conclusions. It is shown that if the methods of chemical-toxicological analysis of prochlorperazine will be presented in corresponding institutions of forensic medical expertise the number of registered cases of poisoning significantly increase, particularly in Ukraine.

Author Biographies

S. I. Merzlikin, National University of Pharmacy

Doctor of Pharmaceutical Science, professor, professor of the Department of Drug and analytical toxicology

T. V. Kucher, Horbachevsky Ternopil State Medical University

Candidate of Pharmaceutical Science, assistant of the Department of Pharmaceutical Chemistry

V. I. Stepanenko, National University of Pharmacy

Candidate of Pharmaceutical Science, assistant professor of the Department of Drug and analytical toxicology

O. H. Pogosyan, National University of Pharmacy

Candidate of Pharmaceutical Science, assistant professor of the Department of Drug and analytical toxicology


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