Study of the anti-exudative activity of dry extract from Prunus Domestica fruits
DOI:
https://doi.org/10.24959/ubphj.19.220Keywords:
Prunus domestica fruits, zymosan-induced edema, exudation, prostaglandins, leukotrienes, hepatoprotectorsAbstract
Topicality. Previous experimental studies of the pharmacological properties of extracts from Prunus domestica fruits revealed the most therapeutically active extract with fibers by laxative and hepatoprotective activities. The hepatoprotective activity of the dry extract from Prunus domestica fruits containing fibers is probably due to the presence of polyphenolic components in the chemical composition of the extract. Based on the analysis of the literature data for polyphenolic compounds, anti-exudative properties are characteristic; therefore, it was reasonable to study the effect of the investigated extract on the cyclooxygenase and lipoxygenase routes of the inflammatory reaction development.
Aim. To investigate experimentally the effect of dry extract from Prunus domestica fruits containing fibers on the development of the anti-exudative phase of inflammation.
Results and discussion. The pretreatment of the animals with extract from Prunus domestica fruits moderately suppressed the development of zymosan-induced edema in all studied periods. Indicators of anti-exudative activity of the studied extract (29.65 %) were lower than activity of reference drug quercetin (36.6 %) and were at the level of indicators of anti-flogogenic manifestations of the reference drug Silybor (29.5 %). The moderate anti-exudative activity of the investigated extract suggests that it suppresses the formation of leukotrienes in the early stages of the inflammatory reaction development (0.5 hours), and prostaglandins – after 3 hours.
Conclusions. Analysis of the experimental data showed a slight anti-cyclo-oxygenase and anti-lipooxygenase activity of the dry extract from Prunus domestica fruits containing fibers. The investigated extract was lower in its ability to inhibit the anti-cyclooxygenase and anti-lipooxygenase pathways of the development of the exudative phase of inflammation than the reference drug quercetin. The moderate anti-inflammatory effect of this extract is probably due to the presence of polyphenolic compounds in its chemical composition.
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