Analytical review of side effects and lethal cases of acute poisoning by antipsychotics and antidepressants
DOI:
https://doi.org/10.24959/ubphj.20.257Keywords:
antipsychotics, antidepressants, poisoning, side effects, chemical-toxicological analysisAbstract
Topicality. Increase in the use of antipsychotics and antidepressants in many countries led to augmentation of acute poisoning amount with lethal cases. Among them, the main part is combined poisoning, including combination with other medicines, which significantly complicates the conduction of chemical-toxicological analysis.
Aim. To conduct the analytical review of side effects and lethal cases of acute poisoning by antipsychotics and antidepressants, including combination with other medicines.
Materials and methods. Analysis of websites and online literature sources such as: ehealthme.com, patientsville.com, Academia.edu, PubMed, ResearchGate, Scopus etc.
Results and discussion. According to the results of sources analysis, in the period from 2013 to 2018, there were registered 5094 cases of side effects and 56 lethal poisonings with the use of the most commonly used antipsychotics of phenothiazine derivatives. Also 6013 cases of side effects and 675 lethal poisonings were registered with the use of tricyclic antidepressants. The main side effects and causes of fatalities have been identified. The combined use of antipsychotics and antidepressants and its simultaneous application with medicines from other pharmacological groups, increases the risk of poisoning. It greatly complicates the chemical and toxicological searches to determine the cause of poisoning.
Conclusions. The conducted research determined the factors of deterioration the toxicological situation recently which has developed with the use of antipsychotics and antidepressants and substantiated feasibility of the development of methods of chemical-toxicological analysis for drugs that caused fatal poisoning.References
Chekman, Y. S., Belenychev, Y. F., Gorchakova, N. A., Bukhtyarova, N. V., Nagornaia E. A. (2018). Ostrye otravleniia lekarstvennymi preparatami : diagnostika, mery neotlozhnoi terapii. Kyiv, Zaporizhia, 100.
Tiihonen, J., Mittendorfer-Rutz, E., Torniainen, M., Alexanderson, K., & Tanskanen, A. (2016). Mortality and Cumulative Exposure to Antipsychotics, Antidepressants, and Benzodiazepines in Patients With Schizophrenia: An Observational Follow-Up Study. American Journal of Psychiatry, 173 (6), 600–606. https://doi.org/10.1176/appi.ajp.2015.15050618
Nedashkivskii, S. M., Galushko, O. A. (2016). Ostrye i neotlozhnye sostoianiia v praktike vracha, 5, 20–28.
Shcho vidomo pro efektyvnist ta bezpeku likarskykh zasobiv v Ukraini? (2018). Available at : https://www.apteka.ua/article/472756
Chekman, I. S., Gorchakova, N. O., Kazak, L. I. (2011). Farmakologiya. Vinnytsia, Nova knyha, 784.
Stroup, T. S., & Gray, N. (2018). Management of common adverse effects of antipsychotic medications. World Psychiatry, 17 (3), 341–356. https://doi.org/10.1002/wps.20567
Desmarais, J. E., Beauclair, L., Annable, L. (2014). Effects of discontinuing anticholinergic treatment on movement disorders, cognition and psychopathology in patients with schizophrenia. Ther Adv Psychopharmacol., 4, 257–267. https://doi.org/10.1177/2045125314553611
Newcomer, J. W., Weiden, P. J., Buchanan. R. W. (2013). Switching antipsychotic medications to reduce adverse event burden in schizophrenia: establishing evidence-based practice. J Clin Psychiatry, 74, 1108–1120. https://doi.org/10.4088/JCP.12028ah1
Gardner, D. M., Abidi, S., Ursuliak, Z. (2015). Incidence of oculogyric crisis and long-term outcomes with second-generation antipsychotics in a first-episode psychosis program. J Clin Psychopharmacol., 35, 715–718. https://doi.org/10.1097/JCP.0000000000000411
Taylor, J., Anderson, W. S., Brandt, J. (2016). Neuropsychiatric complications of Parkinson disease treatments: importance of multidisciplinary care. Am J Geriatr Psychiatry, 24, 1171–1180. https://doi.org/10.1016/j.jagp.2016.08.017
Juncal-Ruiz, M., Ramirez-Bonilla, M., Gomez-Arnau, J., Ortiz-Garcia de la Foz. V., Suarez-Pinilla, P., Martinez-Garcia, O., Neergaard, K. D., Tabares-Seisdedos, R., Crespo-Facorro, B. (2017). Incidence and risk factors of acute akathisia in 493 individuals with first episode non-affective psychosis: a 6-week randomised study of antipsychotic treatment. Psychopharmacology, 234, 2563–2570. https://doi.org/10.1007/s00213-017-4646-1
Carbon, M., Hsieh, C. H., Kane, J. M. Correll, C. U. (2017). Tardive dyskinesia prevalence in the period of second-generation antipsychotic use: a meta-analysis. J Clin Psychiatry, 78, 264–278. https://doi.org/10.4088/JCP.16r10832
Pobichni efekty preparativ. (2019). Available at: https://www.ehealthme.com/
Pobichni efekty preparativ. (2019). Available at: http://patientsville.com/
Pobichni efekty per fenazynu. (2019). Available at: https://www.ehealthme.com/drug/perphenazine/side-effects/
Vypadky peredozuvannia perfenazynom z amitryptylinom. (2019). Available at: https://www.ehealthme.com/condition/amitriptyline-and-perphenazine-overdose/
Merzlikin, S. I., Kucher, T. V., Stepanenko, V. I., Pogosyan, O. G. (2019). Ukrayins`ky`j biofarmacevty`chny`j zhurnal, 2 (59), 14–20. https://doi.org/10.24959/ubphj.19.214
Vypadky suitsydiv prokhlorperazynom. (2019). Available at: http://patientsville.com/prochlorperazine/completed-suicide.htm.
Pobichni efekty proliksynu. (2019). Available at: https://www.ehealthme.com/drug/prolixin/side-effects/
Pobichni efekty Melarylu. (2019). Available at: https://www.ehealthme.com/drug/mellaril/
Kovalenko, V. N. (Ed.). (2015). Kompendium 2015 – lekarstvennye preparaty. Kyiv: Morion, 2448.
Drogovoz, S. M., Lukianchuk, V. D., Sheiman, B. S. (2014). Meditcina neotlozhnykh sostoianii, 2 (57), 90–94.
Rochester, M. P., Kane, A. M., Linnebur, S. A., Fixen, D. R. (2018). Evaluating the risk of QTc prolongation associated with antidepressant use in older adults: a review of the evidence. Ther Adv Drug Saf., 9 (6), 297–308. https://doi.org/10.1177/2042098618772979
Batchvarov, V. N. (2014). The brugada syndrome – diagnosis, clinical implications and risk stratification. Eur Cardiol. 9 (2), 82–87. https://doi.org/10.15420/ecr.2014.9.2.82
Hawton, K., Bergen, H., Simkin, S. Cooper, J., Waters, K., Gunnell, D., Kapur, N. (2010). Toxicity of antidepressants: Rates of suicide relative to prescribing and non-fatal overdose. The British journal of psychiatry: the journal of mental science. 196 (5), 354–358. https://doi.org/10.1192/bjp.bp.109.070219
Sheridan, D., Lin, A., Horowitz, B. Z. (2018). Suicidal bupropion ingestions in adolescents: increased morbidity compared with other antidepressants. Clin Toxicol (Phila), 56 (5), 360–364.
Coupland, С., Hill, T., Morriss, R., Arthur, A., Moore, M., Hippisley-Cox, J. (2015). Antidepressant use and risk of suicide and attempted suicide or self harm in people aged 20 to 64: cohort study using a primary care database. BMJ, 350, 517–530. https://doi.org/10.1136/bmj.h517
White, N., Litovitz, T., Clancy, C. (2008). Suicidal antidepressant overdoses: a comparative analysis by antidepressant type. J Med Toxicol., 4, 238–250. https://doi.org/10.1007/BF03161207
Baun, B. T., Brinon, M., Larsen, K. G. (2018). Sotcialnaia i klinicheskaia psikhiatriia, 2, 45–49.
Li, W., Lamichhane, J. (2017). From heartbreak to left bundle branch block: a case of amitriptyline overdose. American Journal of Therapeutics, 24, 621–623. https://doi.org/10.1097/MJT.0000000000000614
Kiberd, M. B., Minor, S. F. (2012). Lipid therapy for the treatment of a refractory amitriptyline overdose. CJEM, 14, 193. https://doi.org/10.2310/8000.2011.110486
Pobichni efekty amitryptylinu. (2019). Available at: https://www.ehealthme.com/drug/amitriptyline-hydrochloride/side-effects/
Vypadky suitsydu nortryptylinom. (2019). Available at: http://patientsville.com/nortriptyline/completed-suicide.htm
Pobichni efekty imipraminu hidro khlorydu. (2019). Available at: https://www.ehealthme.com/drug/imipramine-hydrochloride/side-effects/
Vypadky suitsydu imipraminom. (2019). Available at: http://patientsville.com/imipramine/completed-suicide.htm#.XcBvgK9wnIU
Pobichni efekty dezypraminu. (2019). Available at: https://www.ehealthme.com/drug/desipramine-hydrochloride/side-effects/
Vypadky suitsydu dezypraminom. (2019). Available at: http://patientsville.com/desipramine/completed-suicide.htm#.XcBw0a9wnIU
Vypadky suitsydu amoksapinom. (2019). Available at: http://patientsville.com/amoxapine/completed-suicide.htm
Pobichni efekty maprotylinu. (2019). Available at: http://patientsville.com/maprotiline/#.XcB0xa9wnIU
Vypadky suitsydu mirtazapinom. (2019). Available at: http://patientsville.com/mirtazapine/completed-suicide.htm#.XcB2Sa9wnIU
Tcipriani, A. Furukama, T. A., Salanti, Dzh. (2018). Sotcialnaia i klinicheskaia psikhiatriia, 4, 61–69.
Medvedev, V. E. (2012). Psikhiatriia i psikhofarmakoterapiia, 1, 53–56.
Vieweg, W. V., Wood, M. A., Fernandez, A., Beatty-Brooks, M., Hasnain, M., Pandurangi, A. K. (2009). Proarrhythmic risk with antipsychotic and antidepressant drugs: implications in the elderly. Drugs Aging, 26(12), 997–1012.
Pobichni efekty tryavilu. (2019). Available at: https://www.ehealthme.com/drug/triavil-2-25/side-effects/
Sobennikov, V. S. (2013). Zhurnal nevrologii i psikhiatrii im. S. S. Korsakova, 2, 20–24.
Kondratenko, S. N., Saveleva, M. I., Kukes, V. G., Shikh, E. V., Gneushev, E. T. (2019). Biulleten eksperimentalnoi biologii i meditciny, 3, 330–337.
Mao, Y. M., Zhang, M. D. (2015). Augmentation with antidepressants in schizophrenia treatment: benefit or risk. Neuropsychiatr Dis Treat, 16, 701–713. https://doi.org/10.2147/NDT.S62266
Zink, M., Englisch, S., Meyer-Lindenberg, A. (2010). Polypharmacy in schizophrenia. Curr Opin Psychiatry, 23 (2), 103–111. https://doi.org/10.1097/YCO.0b013e3283366427
Zotov, P. B., Prilenskii, A. B. (2017). Suitcidologiia, 4(29), 98–106.
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