Study of phenolic composition of medicine in the form of androgenic action capsules
DOI:
https://doi.org/10.24959/ubphj.20.262Keywords:
androgenic action, capsules, identification, phenolic compounds, quality indicatorsAbstract
Topicality. Taking into account sexual pathologies prevalence and the male fertility reduction , as well as the limited availability of medicines for the prevention and treatment of these disorders in the pharmaceutical market of Ukraine, it is important to expand their nomenclature by creating new extemporal medicines based on natural raw materials and amino acids.
Aim. To identify the phenolic compounds of developed extemporal medicine in the form of androgenic action capsules.
Materials and methods. The study of phenolic composition of the developed medicine under the conditional name “Apinin” has been carried out using the methods specified in the State Pharmacopoeia of Ukraine, results of which allowed to evaluate objectively the developed capsules quality.
Results and discussion. During the conducted studies of the phenolic compounds identification, it was found the appearence of identical spots on chromatograms of tested alcoholic solution of “Apinin” capsules and FGPP alcoholic solution. Correspondence to compounds of phenolic nature: phenolecarboxylic acids, oxycoumarins, and flavones, as well as flavonols, are revealed. It was established that excipients introduced into the formulation do not interfere with the release of phenolic compounds from the formulation. The quantitative determination of phenolic compounds in the medicine performed by absorption spectrophotometry in the UV-region using a SF-46 device, followed by computerized processing of results of the study using the Spectrum software for Windows. The quantitative content of the amount of phenolic compounds in the medicine “Apinin” was determined, which amounts to 0.028 ± 0.001 g per capsule.
Conclusions. Methods for determining the qualitative composition of phenolic compounds of FGPP and their quantitative content in androgenic action capsules of extemporal production have been developed. One-way ascending chromatography on paper used to identify active pharmaceutical ingredients, and a spectrophotometric method used to study the quantitative content of phenolic compounds in medicine. Tests have been performed according to methods of the State Pharmacopoeia of Ukraine.
References
Zaichenko, A. V., Andriianenkov, A. B., Iaroshenko, I. V. (2014). Perspektivy sozdaniia novykh korrektorov seksualnykh rasstroistv na osnove substantcii prirodnogo proiskhozhdeniia. Provizor, 11-12, 16–21.
Reznikov, O. H. (Ed.). (2010). Doklinichne vyvchennia likarskykh zasobiv, pryznachenykh dlia likuvannia prostatytiv : metod. rek. Kyiv : Avitsenna, 30.
Tykhonov, O. I., Romas, K. P. (2010). Patent 54662 Ukrainy na korysnu model MPK (2009) A61K 9/48, A61K 31/198, A61K 35/64, A61K 5/26. Likuvalno-profilaktychnyi zasib u formi kapsul androhennoi dii.
Tykhonov, O. I., Romas, K. P. (2011). Patent 96068 Ukrainy na vynakhid MPK A61K 9/48 (2006.01), A61K 31/198 (2006.01), A61K 35/64 (2006.01), A61K 5/26 (2006.01). Likuvalno-profilaktychnyi zasib u formi kapsul androhennoi dii.
Havsteen, B. H. (2002). The biochemistry and medical significance of the flavonoids. Pharmacology & Therapeutics, 96 (2-3), 67–202. https://doi.org/10.1016/s0163-7258(02)00298-x
Duarte, S., Koo, H., Bowen, W. H., Hayacibara, M. F., Cury, J. A., Ikegaki, M., & Rosalen, P. L. (2003). Effect of a Novel Type of Propolis and Its Chemical Fractions on Glucosyltransferases and on Growth and Adherence of Mutans Streptococci. Biological & Pharmaceutical Bulletin, 26 (4), 527–531. https://doi.org/10.1248/bpb.26.527
Popova, M. P., Bankova, V. S., Bogdanov, S., Tsvetkova, I., Naydenski, C., Marcazzan, G. L., & Sabatini, A.-G. (2007). Chemical characteristics of poplar type propolis of different geographic origin. Apidologie, 38 (3), 306–306. https://doi.org/10.1051/apido:2007013
Derzhavna farmakopeia Ukrainy: (Vols 3). (2015). DP “Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv” (2-edition). Kharkiv : DP “Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv”, 1, 1128.
Romas, K. P., Tykhonov, O. I. (2011). Kilkisne vyznachennia arhininu u kapsulakh “Apinin” metodom vysokoefektyvnoi ridynnoi khromatohrafii. Visnyk farmatsii, 2, 37–40.
Romas, K. P., Ganzhola, K. A. (2018). Issledovanie farmako-tekhnologicheskikh kharakteristik androgennogo preparat. Innovatcii v meditcine i frarmatcii, 845–848.
Bobro, S. G., Tikhonov, A. I., Blazheyevskiy, M. Y. (2015). Quantitive determination of azelaic acid in “Propolis” gel with the propolis phenoic hydrophobic drug for treating acne. Journal of Pharmacy and Pharmacology, 3, 73–79.
Heorhiyevsʹkyy, V., Lyapunov, M., Bezuhla, O., Piotrovskaia, A., Grizodub, A. (2004). Nastanova 42-3.3:2004 Nastanovy z yakosti. Likarski zasoby. Vyprobuvannia stabilnosti. Kyiv: MOZ Ukrayiny, 60.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
