Study of antimicrobial activity of apricot fruits extracts

Authors

DOI:

https://doi.org/10.24959/ubphj.20.265

Keywords:

Armeniaca vulgaris, dried fruit extracts, antimicrobial activity

Abstract

Topicality. Today, treatment of infectious diseases is considered to be one of the actual problems in pharmacy and medicine. The spectrum of antimicrobial agents used to fight pathogens, due to the developed problem of antibiotic resistance, is steadily narrowing. Therefore, finding new drugs with antibacterial and antifungal activity is an important task.

Aim. To study the antimicrobial activity of Armeniaca vulgaris dried fruit extracts.

Materials and methods. The object of the study were Armeniaca vulgaris dried fruits. The antibacterial and antifungal activity of the extracts was determined in vitro experiments by diffusion into agar (“wells” method).

Results and discussion. The extractable matters content ranges from 2.47 to 7.30 % for alcohol extracts in neutral medium and from 3.78 to 8.03 % in acidified medium. When extracted with methylene chloride, the extractable matters content is much lower. The results of the study of extracts for antimicrobial activity showed that all microorganisms strains are sensitive to the samples.

Conclusions. All samples tested have antimicrobial activity against the microorganisms strains used. Most alcoholic extracts obtained by acidification exhibit higher inhibitory activity than neutral samples.

Author Biographies

A. Kutsanyan, Natioal University of Pharmacy

student

N. Popova, Natioal University of Pharmacy

Doctor of Pharmacy, Professor, the Department of Chemistry of Natural Compounds and Nutritiology

M. Komisarenko, National University of Pharmacy

assistant, the Department of Pharmacognosy

T. Osolodchenko, Mechnikov Institute of Microbiology and Immunology of the NAMS of Ukraine

PhD in Biology, senior researcher, head of the Laboratory of Biochemistry and Biotechnology

V. Litvinenko, State Enterprise “State Scientific Center for Drugs and Medicinal Products”

Doctor of Chemistry, Professor, head of the Department of Chemistry and Technology of Phenolic Drugs

References

Popova, N. V., Litvinenko, V. I., Kutcanian, A. S. (2016). Lekarstvennye rasteniia mirovoi flory: entcikloped. spravochnik. Kharkov : Dіsa plius, 540.

Hrodzinskyi, M. (Ed.). (1991). Likarski roslyny: entsyklopedychnyi dovidnyk. Kyiv : Holov. red. ukr. rad. Entsyklopedii im. M. P. Bazhana, 544.

Chernykh, V. P. (Ed.). (2016). Farmatsevtychna entsyklopediia (3-edition). Kyiv : MORION, 1952.

WHO guidelines on good agricultural and collection practices (GACP) for medicinal plants. (2003). World Health Organization Geneva, 72.

Derzhavna farmakopeia Ukrainy : (Vols 3). (2015). DP “Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv” (2-edition). Kharkiv: DP “Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv”, 1, 1128.

Vyvchennia spetsyfichnoi aktyvnosti protymikrobnykh likarskykh zasobiv. (2004). Metodychni rekomendatsii. Kyiv: 38.

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Published

2020-06-04

Issue

No. 2(63) (2020)

Section

Microbiological research

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