Study of the unfluence of aqueous extracts and tinctures from medicinal plants on the lipid metabolism indicators in hypothyroid animals
Keywords:medicinal plants, extracts, tinctures, hypothyroidism, lipid metabolism
Topicality. Scientific medicine has practically no herbal remedy for the treatment of hypothyroidism and thyrotoxicosis, while in folk medicine there are many medicinal plants used for this purpose in the form of infusions or decoctions. Search and production of potential herbal remedies for complex therapy of thyroid diseases is an urgent task of pharmacy.
Aim. To study the influence of various pharmaceutical forms of medicinal plants on metabolic processes in animals with hypothyroidism.
Materials and methods. The indicators of lipid metabolism has been determined in the serum: total lipids, triglycerols, total cholesterol, HDL and LDL. Experimental hypothyroidism has been induced by the daily administration of 1 % solution of sodium perchlorate for 20 days. Iodomarin used as a reference drug.
Results and discussion. In animals with hypothyroidism, hyperlipidemia, hypertriacylglycerolemia, hypercholesterolemia and increase in LDL level by 19 % have been identified. The corrective effect of the investigated agents on the lipid metabolism parameters in rats with experimental hypothyroidism has been established. Aqueous extracts had a more pronounced normalizing effect. Among the investigated medicinal plants, Fucus vesiculosus showed the effect on the level of the reference drug Iodomarin.Conclusions. The investigated aqueous extracts and tinctures from Cetraria islandica, Fucus vesiculosus and grass of Genista tinctoria have showed a normalizing effect on lipid metabolism with different rate and could be considered as potential herbal remedies for improving metabolic disorders in hypothyroidism.
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