Study of the specific activity of anthelmintic drug “Ap-helmin”

Authors

DOI:

https://doi.org/10.24959/ubphj.20.271

Keywords:

anthelmintic drugs, albendazole, praziquantel, nematodosis, cestodosis, pharmacological studies

Abstract

Topicality. The problem of infectious and parasitic diseases and, in particular, helminthiases of various etiologies, has acute social significance in the modern world. The active spread of pathogens, including those that are not typical for certain regions and countries, neglection of personal hygiene rules and problems in the field of medical insurance lead to an increase in the incidence of diseases among the population both in countries with insufficient levels of medical development, and in highly developed countries.

Aim.  To study the specific pharmacological activity of an anthelmintic drug that combines albendazole and praziquantel in a ratio of (1 : 4) using spontaneous paraspidoderosis (nematodosis) and hymenolepidosis (cestodosis) in white rats as an example.

Materials and methods. The studies have been carried out in the coproscopic laboratory of the Department of Parasitology of the Kharkov State Zooveterinary Academy according to the standardized Fulleborn method and “Method for the quantitative determination of helminth eggs” (patent No. 9265).

Results and discussion. The results obtained indicate the absolute effectiveness of the study drug. The results of a clinical examination of animals showed that the behavior of the animals did not change (natural), the intake of food and water was normal, the visible mucous membranes were pale pink, the skin was holistic, without damage, and the skin was elastic.

Conclusions. Based on the results obtained, it can be concluded that the studied drug under the conditional name “AP-helmin” has a high level of specific pharmacological activity.

Author Biographies

K. Semchenko, National University of Pharmacy

PhD of Pharmacy, Associate Professor of Department of Pharmaceutical Technology of Drugs

L. Vyshnevska, National University of Pharmacy

Doctor of Pharmacy, Head of Department of Pharmaceutical Technology of Drugs

References

Helmintozy – chy ye aktualnoiu tsia problema? (n.d.). Available at: http://www.gvkg.kiev.ua/index.php/informatsiia-dlia-khvorykh-fiz/778-helmintozy-chy-ie-aktualnoiu-tsia-problema

Hlysty – shkidlyvi “kvartyranty” liudyny. (n.d.). Available at: http://www.rouoz.gov.ua/health/prevention/?sid=32

Samura, B. A., Babak, O. Ya., Kolesnyk, Yu. M. (Eds.). (2010). Farmakoterapyia : ucheb. dlia stud. vuzov: 4-e yzd., pererab y dop. Kharkiv: Zolotie stranytsi, 800.

Derzhavnyi reiestr likarskykh zasobiv. (n.d.). Available at: http://www.drlz.com.ua/ibp/ddsite.nsf/all/shlist?opendocument

Nastanova 00020. Askarydoz. (n.d.). Available at: http://guidelines.moz.gov.ua/documents/2918?id=ebm00020&format=pdf

Nastanova 00019. Hostryky (enterobioz). (n.d.). Available at: http://guidelines.moz.gov.ua/documents/2918?id=ebm00019&format=pdf

Nastanova 00021. Kyshkovitsestodozy. (n.d.). Available at: http://guidelines.moz.gov.ua/documents/2918?id=ebm00021&format=pdf

Nastanova 01039. Nematodozy. (n.d.). Available at: http://guidelines.moz.gov.ua/documents/2918?id=ebm01039&format=pdf

Nastanova 01038. Stronhiloidoz. (n.d.). Available at: http://guidelines.moz.gov.ua/documents/2918?id=ebm01038&format=pdf

Nastanova 01043. Trykhotsefaloz. (n.d.). Available at: http://guidelines.moz.gov.ua/documents/2918?id=ebm01043&format=pdf

Tolochko, K., & Vyshnevska, L. (2017). Analysis of the domestic pharmaceutical market of anthelmintic medicines. News of Pharmacy, 1 (89), 56–60. http://dx.doi.org/10.24959/nphj.17.2157

Semchenko, K. V., Vyshnevska, L. I. (2019). Pat. № u201910233. Antyhelmintnyi zasib na osnovi albendazolu ta prazykvantelu. Ukraina, MPK (2019.1): A61K 31/4184, A61K 31/47, A61P 33/00.

Semchenko K. V., Vyshnevska L. I. (2019). Pat. № a201910236. Antyhelmintnyi zasib na osnovi albendazolu ta prazykvantelu; Ukraina, MPK (2019.1): A61K 31/4184, A61K 31/47, A61P 33/00.

Mazannyi, O. V., Byrka, V. I., Prykhodko, Yu. O. (2005). Pat. na korysnu model № 9265, Ukraina MPK51, G01N 33/487. № u200502006.

Published

2020-06-04

Issue

Section

Pharmacology and biochemistry