Study of the specific activity of anthelmintic drug “Ap-helmin”
Keywords:anthelmintic drugs, albendazole, praziquantel, nematodosis, cestodosis, pharmacological studies
Topicality. The problem of infectious and parasitic diseases and, in particular, helminthiases of various etiologies, has acute social significance in the modern world. The active spread of pathogens, including those that are not typical for certain regions and countries, neglection of personal hygiene rules and problems in the field of medical insurance lead to an increase in the incidence of diseases among the population both in countries with insufficient levels of medical development, and in highly developed countries.
Aim. To study the specific pharmacological activity of an anthelmintic drug that combines albendazole and praziquantel in a ratio of (1 : 4) using spontaneous paraspidoderosis (nematodosis) and hymenolepidosis (cestodosis) in white rats as an example.
Materials and methods. The studies have been carried out in the coproscopic laboratory of the Department of Parasitology of the Kharkov State Zooveterinary Academy according to the standardized Fulleborn method and “Method for the quantitative determination of helminth eggs” (patent No. 9265).
Results and discussion. The results obtained indicate the absolute effectiveness of the study drug. The results of a clinical examination of animals showed that the behavior of the animals did not change (natural), the intake of food and water was normal, the visible mucous membranes were pale pink, the skin was holistic, without damage, and the skin was elastic.Conclusions. Based on the results obtained, it can be concluded that the studied drug under the conditional name “AP-helmin” has a high level of specific pharmacological activity.
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