Biochemical role of pancreatic NMDA receptors in the pathogenesis of carbohydrate metabolism disorders

Authors

  • Т. Briukhanova National University of Pharmacy of the Ministry of Health of Ukraine http://orcid.org/0000-0002-8042-9063
  • L. Galuzinska National University of Pharmacy of the Ministry of Health of Ukraine

DOI:

https://doi.org/10.24959/ubphj.20.279

Keywords:

type 2 diabetes, insulin resistance, pancreatic NMDA receptors, carbohydrate metabolism

Abstract

According to World Health Organization expert estimates, type 2 diabetes mellitus (DM2) remains the most common disease, which characterized by persistent disorders of almost all metabolic links.

Aim. To conduct an analytical review of available literature on the biochemical role of pancreatic NMDA receptors in the pathogenesis of carbohydrate metabolism disorders.

Materials and methods. Open-source analysis of the academic and scientific literature.

Results and discussion. According to the examined data, modulation of the activity of extraneuronal receptors, such as pancreatic NMDA receptors, may affect the regulation of carbohydrate metabolism, in particular glucose-stimulated insulin secretion and blood glucose homeostasis. Therefore, it is considered to be of high relevance to study those drugs that block pancreatic receptors to use them as the basis in the creation of new antidiabetic drugs.

Conclusions. NMDAR antagonists can be considered as new potential antidiabetic drugs that not only normalize blood glucose levels, but also have a protective effect onto islet cells. The use of NMDAR antagonists as adjunctive therapy in diabetes mellitus pharmacological correction regimens may be useful in inhibiting disease progression.

Author Biographies

Т. Briukhanova, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Biological Sciences, assistant of the Department of Biological Chemistry

L. Galuzinska, National University of Pharmacy of the Ministry of Health of Ukraine

Candidate of Pharmacy (Ph.D), associate professor of Department of the biological chemistry department

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Published

2020-09-18

Issue

Section

Review articles