DOI: https://doi.org/10.24959/ubphj.20.280

Theoretical justification of the choice of API in the composition of extemporal gel for treatment of wounds and bedsores

G. Melnyk, T. Yarnykh, M. Buryak

Abstract


Topicality. Treatment of chronic wounds and bedsores remains an urgent problem today, which requires the development of effective and safe drugs. Regardless of the cause, the pathogenesis of chronic wounds and bedsores is based on violations of trophic and protective properties of the skin, which develop due to tissue hypoxia.

Aim. The aim of this work is theoretical research to substantiate the choice of active pharmaceutical ingredients (API) in the composition of extemporaneous gel for the treatment of chronic wounds and bedsores.

Materials and methods. Methods of systematic and comparative analysis and bibliosemantic method of studying the modern view on the treatment of chronic wounds and the use of API for their treatment were used to search for information.

Results and discussion. The article shows the relevance of the use of active pharmaceutical ingredients (decamethoxine and hyaluronic acid). Analysis of the literature showed that decamethoxine has a pronounced antibacterial, fungicidal and virocidal action, as well as has anti-inflammatory activity; hyaluronic acid - stimulates repair processes and accelerates epithelialization of wounds.

Conclusions. The choice of API (decamethoxine and hyaluronic acid) in the composition of extemporaneous gel for the treatment of wounds and bedsores is theoretically substantiated.

Keywords


pharmacotherapy; chronic wounds; bedsores; decamethoxine; hyaluronic acid; extemporaneous gel

References


Bekara, F., Vitse, J., Fluieraru. S., Masson, R., Runz, A., Georgescu, V. et al. (2018). New techniques for wound management: A systematic review of their role in the management of chronic wounds. Arch Plast Surg., 45 (2), 102-110. doi: 10.5999/aps.2016.02019.

Ilenghoven, D. A. (2017). Review of Wound Dressing Practices. Clinical Dermatology Open Access Journal, 2 (6), 1-12. doi: 10.23880/CDOAJ-16000133.

Cwaliński, J., Paszkowski, J., Banasiewicz, T. (2018). New perspectives in the treatment of hard-to-heal wound. Wound Therapy Journal, 5 (4), 10-12. doi: 10.18487/npwtj.v5i4.45.

Frykberg, R. G., Jaminelli, B. (2015). Challenges in the Treatment of Chronic Wounds. Advances in Wound Care, 4 (9), 560-582. doi: 10.1089/wound.2015.0635.

Colenci, R. L., Abbade, P. F. (2018). Fundamental aspects of the local approach to cutaneous ulcers. Analytic Bras Dermatology, 93 (6), 859-70. doi: 10.1590/abd1806-4841.20187812.

Lim, K., Free, B., Sinha, S. (2015). Modified TIME-H: a simplified scoring system for chronic wound management. Journal Wound Care, 24 (9), 415-419. doi: 10.12968/jowc.2015.24.9.415.

Laurel, Mt. (2015). Methods of Wound Debridement: Best Practice for Clinicians. Wound, Ostomy and Continence Nurses Society™. Available from: https://cdn.ymaws.com/www.wocn.org/resource/resmgr/Publications/Methods_of_Wound_Debridement.pdf?hhSearchTerms=».

El-Sabbagh, A. H. (2017). Negative pressure wound therapy: An update. Chin J Traumatol, 20 (2), 103-107. doi: 10.1016/j.cjtee.2016.09.004.

Johani, K., Malone, M., Jensen, S. O. (2018). Evaluation of short exposure times of antimicrobial wound solutions against microbial biofilms: from in vitro to in vivo. Journal of Antimicrobial Chemotherapy, 73 (2), 494-502. doi: 10.1093/jac/dkx391.

Aya, K. L., Stern, R. (2015). Hyaluronan in wound healing: rediscovering a major player. Wound Repair Regen., 5, 579–93. doi: 10.1111/wrr.12214.

Voigt, J., Driver, V. R. (2012). Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: A systematic review and meta-analysis of randomized controlled trials. Wound Repair and Regeneration, 20 (3), 317-331. doi: 10.1111/j.1524-475X.2012.00777.x.

Snetkov, P., Morozkina, S., Uspenskaya, M., Olekhnovich, R. (2019). Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application. Polymers (Basel), 11 (12), 2032-2036. doi: 10.3390/polym11122036.

Longinotti, C. (2014). The use of hyaluronic acid based dressings to treat burns: A review. Burn Trauma, 2, 162–168. doi: 10.4103/2321-3868.142398.

Manna, B., Morrison, C. A. (2020). Wound Debridement. Treasure Island (FL): StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK507882/.


GOST Style Citations


1.   New techniques for wound management: A systematic review of their role in the management of chronic wounds / F. Bekara et al. Arch Plast Surg. 2018. № 45 (2). P. 102–110. DOI: https://doi.org/10.5999/aps.2016.02019 (Date of access: 12.07.2020).

 

2.   Ilenghoven D. A. Review of Wound Dressing Practices. Clinical Dermatology Open Access Journal. 2017. № 2 (6). P. 1–12. DOI: 10.23880/CDOAJ-16000133 (Date of access: 12.07.2020).

 

3.   Cwaliński J., Paszkowski J., Banasiewicz Т. New perspectives in the treatment of hard-to-heal wound. Wound Therapy Journal. 2018. № 5 (4). P. 10–12. DOI: 10.18487/npwtj.v5i4.45 (Date of access: 12.07.2020).

 

4.   Frykberg R. G., Jaminelli B. Challenges in the Treatment of Chronic Wounds. Advances in Wound Care. 2015. № 4 (9). P. 560–582. DOI: 10.1089/wound.2015.0635 (Date of access: 12.07.2020).

 

5.   Colenci R. L., Abbade P. F. Fundamental aspects of the local approach to cutaneous ulcers. An Bras Dermatol. 2018. № 93 (6). P. 859–870. DOI: https://doi.org/10.1590/abd1806-4841.20187812 (Date of access: 12.07.2020).

 

6.   Lim K., Free B., Sinha S. Modified TIME-H: a simplified scoring system for chronic wound management. Jornal Wound Care. 2015. № 24 (9). P. 415–419. DOI: https://doi.org/10.12968/jowc.2015.24.9.415 (Date of access: 12.07.2020).

 

7.   Laurel Mt. Methods of Wound Debridement: Best Practice for Clinicians. Wound, Ostomy and Continence Nurses Society™. 2015. URL: https://cdn.ymaws.com/www.wocn.org/resource/resmgr/Publications/Methods_of_Wound_Debridement.pdf?hhSearchTerms=» (Date of access: 12.07.2020).

 

8.   El-Sabbagh A. H. Negative pressure wound therapy: An update. Chin Journal Traumatology. 2017. № 20 (2). P. 103–107. DOI: https://doi.org/10.1016/j.cjtee.2016.09.004 (Date of access: 12.07.2020).

 

9.   Johani К., Malone М., Jensen S. O. Evaluation of short exposure times of antimicrobial wound solutions against microbial biofilms: from in vitro to in vivo. Journal of Antimicrobial Chemotherapy. 2018. Vol. 2, № 73 (2). P. 494–502. DOI: 10.1093/jac/dkx391 (Date of access: 12.07.2020).

 

10. Aya K. L., Stern R. Hyaluronan in wound healing: rediscovering a major player. Wound Repair Regen. 2015. № 5. P. 579–93. DOI: 10.1111/wrr.12214 (Date of access: 12.07.2020).

 

11. Voigt J., Driver V. R. Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: A systematic review and meta-analysis of randomized controlled trials. Wound Repair and Regeneration. 2012. Vol. 20, № 3. Р. 317–331. DOI: 10.1111/j.1524-475X.2012.00777.x (Date of access: 12.07.2020).

 

12. Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application / P. Snetkov et al. Polymers (Basel). 2019. № 11 (12). Р. 2032–2036. DOI: https://doi.org/10.3390/polym11122036 (Date of access: 12.07.2020).

 

13. Longinotti C. The use of hyaluronic acid based dressings to treat burns: A review. Burn. Trauma. 2014. № 2. P. 162–168. DOI: https://doi.org/10.4103/2321-3868.142398 (Date of access: 12.07.2020).

 

14. Manna B., Morrison C. A. Wound Debridement. Treasure Island (FL): StatPearls Publishing. 2020. URL: https://www.ncbi.nlm.nih.gov/books/NBK507882/ (Date of access: 12.07.2020).





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Abbreviated key title: Ukr. biopharm. j.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)