Phytochemical and pharmacological study of the distillation extract from Salvia officinalis leaves

Authors

  • G. V. Vovk National University of Pharmacy, Ukraine
  • M. M. Myga National University of Pharmacy, Ukraine
  • O. M. Koshovyi National University of Pharmacy, Ukraine
  • Yu. V. Verkhovodova National University of Pharmacy, Ukraine
  • I. V. Kireev National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/ubphj.16.10

Keywords:

Salvia officinalis, leaves, distillation, liquid extract, chemical composition, anti-inflammatory activity

Abstract

On the Ukrainian market there are more than 40 medicines, which contain biological active substances of sage leaves. They essentially includes an essential oil. Wastes from the production of sage essential oil are tons of water distillation extract, so the purpose of the research was to investigate a chemical composition and pharmacological activity of the distillation extract from Salvia officinalis leaves. The dry residue in the distillation extract was 2.49%. The liquid extract of sage leaves contains 10 free and 11 linked amino acids. The dominant ones are tyrosine, serine, glutamic and aspartic acid. Free amino acid assay are 0.48% and the related - 0.63%. The liquid extract by HPLC revealed 12 phenolic substances, including 3 hydroxycinnamic acids - coffee, rosemarinic and chlorogenic; 6 flavonoids - apigenin, luteolin, quercetin, 3-metoksiluteolin, luteolin-7-O-glycoside and quercetin-3-O-arabinoside. The study of the Salvia officinalis leaves liquid extract established assay of hydroxycinnamic acids (0,212 ± 0,041%), flavonoids (0,054 ± 0,002%) and phenolic compounds (1,204 ± 0,031%). The sage liquid extract pronounced anti-inflammatory activity.

Author Biography

G. V. Vovk, National University of Pharmacy

аспірант кафедри фармакогнозії Національного фармацевтичного університету

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Published

2016-02-04

Issue

No. 1(42) (2016)

Section

Pharmaceutical chemistry and pharmacognosy

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Copyright (c) 2016 National University of Pharmacy

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