The screening studies on the hypoglycemic action new amide derivatives of dicarboxylic acids

Authors

  • N. G. Vakhnina National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/ubphj.16.5

Keywords:

malonic acid, oxalic acid, hypoglycemic action

Abstract

The article have been devoted to screening tests hypoglycemic action of 43 new derivatives of malonic and oxalic acids. Studies carried out on rabbits with normal blood glucose. The studied compounds were administered at a dose of 1/20 LD50. Comparison drug was chosen bucarban a dose of 50 mg / kg. The relationship "structure - hypoglycemic effect" have been installed for new derivatives of dicarboxylic acids - amides of malonic and oxalic acids. A promising for further research is a compound under the laboratory code number 21, which is at a dose of 13,3 mg / kg shows a pronounced hypoglycemic effect on the level of the reference drug bucarban a dose of 50 mg / kg.

References

Доклінічні дослідження лікарських засобів: метод. рек. / за ред. О. В. Стефанова. – К. : Авіцена, 2001. – 528 с.

Программа статистического анализа. Режим электронного доступа www.analystsoft.com/ru

Рєзников О. Г. Загальні етичні принципи експериментів на тваринах / О. Г. Рєзников // Ендокринологія. – 2003. – Т. 8, № 1. – С. 142–145.

Adherence to Therapies in Patients with Type 2 Diabetes /L.-E. García-Pérez, M. Álvarez, T. Dilla, et. al. //Diabetes Ther.- 2013.- Vol. 4(2).-P. 175–194.

Chaparro M. New molecules in the treatment of inflammatory bowel disease / M. Chaparro, J.P. Gisbert //Gastroenterol Hepatol. – 2015. – Vol. 26. – Р.210-215.

Diabetes and related remedies in medieval Persian medicine /Mohammad M. Zarshenas А., Khademian S., et. al. //Indian J Endocrinol Metab. 2014.- Vol. 18(2): 142–149.

Huri H. Z. Drug-related problems in type 2 diabetes mellitus patients with dyslipidemia / H. Z. Huri, L. C. Ling //BMC Public Health. – 2013. -Vol.13.- P. 1192-1194.

Standards of Medical Care in Diabetes—2013 //American Diabetes Association. Diabetes Care.- 2013.- Vol. 36 (Suppl 1): S11–S66.

Vlassara H. AGE restriction in diabetes mellitus: a paradigm shift / H.Vlassara, Gary E. Striker // Nat Rev Endocrinol. 2011.- Vol. 24; 7(9). – P.526–539.

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Published

2016-02-04

Issue

No. 1(42) (2016)

Section

Pharmacology and biochemistry

License

Copyright (c) 2016 National University of Pharmacy

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