The studying of antioxidant activity of salts 2-((4-R-3-(morpholinomethylen)-4H-1,2,4-triazole-5-yl)thio)acetic acids

R. O. Shcherbyna, O. I. Panasenko, Ye. H. Knysh


In this work we have conducted the synthesis, the establishment of physical-chemical properties and subsequent Pass-screening of possible biological activity for new alkyl derivatives of 4-R-3-(morfolinometylen)-4H-1,2,4-triazole-5-thioles. According to the results of computer prediction it was found that it is advisable to perform in vivo studies for these substances on the ability to use in the treatment of hastrinomy, ulcers, tuberculosis, atherosclerosis and for eradication of Helicobacter Pylori.


1,2,4-triazole; synthesis; prediction of biological activity


The State Veterinary and Phytosanitary Service of Ukraine. List of registered veterinary products, feed additives, premixes and finished feeds, 2009-2015 // [WWW document]. URL http:// (the 11 of January 2016).

Kazicyna L. A. Application of UV-, YK-, NMR- and MASS- spectroscopy in the Organic Chemistry / L. A. Kazicyna. – 2 edit., revised and expanded. – М.: Publish. Moscow University, 1979. – 236 p.

Saidov T. V. Practical Guide to Molecular Spectroscopy / T. V. Saidov, О. V. Sverdlova. – L.: Publish. SPU, 1995. – 236 p.

Synthesis and physicochemical properties of 2-((4-R-3-(morfolinometylen)-4H-1,2,4-triazole-5-yl)tio) acetic acids / R. O. Shcherbyna, O. I. Panasenko, Ye. H. Knysh, Varinskiy B. O. // Current issues of Pharmaceutical and Medical science and practice. – Zaporizhya, 2014. – № 3. – P. 18–21.

Shcherbyna R. O. PASS-screening of possible types biological activity 2-(4H-1,2,4-triazole-3-yltio)acetаldehyde derivatives / R. O. Shcherbyna, O. I. Panasenko, Ye. H. Knysh // Medical Chemistry. – 2011. – № 3 (48). – P. 81–84.

Shcherbyna R. O. Pharmacological activity analysis of the 1,2,4-triazole derivatives / R. O. Shcherbyna // Pharmaceutical Journal. – 2014. – № 4. – P. 145–150.

Brenner G. M. Pharmacology / Brenner G. M., Stevens C. W. - 4st ed. Philadelphia, PA: Elsevier/Saunders, 2012. - 528 p.

Poroikov V. PASS: Prediction of Biological Activity Spectra for Substances / Poroikov V., Filimonov D. // Predictive Toxicology / ed. by Christoph Helma. – N.Y. : Marcel Dekker, 2005. – P. 459–478.

Triazole as pharmaceutical potentials / Rakesh Kumar, Mohd. Shahar Yar., Saurabh Chaturvedi [et al.] // International Journal of PharmTech Research. – 2013. ‒ Vol.5, №4. – P. 1844-1869.

X Madden T. LC-MS in drug bioanalysis / X Madden T. ‒ New York: Springer, 2012. ‒ 472 p.

GOST Style Citations


Abbreviated key title: Ukr. bìofarm. ž.

ISSN 2519-8750 (Online), ISSN 2311-715X (Print)