Data of liver tissue morphometric investigation of the rats of different ages on the base of chronic alcohol intoxication and after quercetin and L-arginine L-glutamate introduction

Authors

  • L. O. Yarovenko National Pirogov Memorial Medical University

DOI:

https://doi.org/10.24959/ubphj.16.8

Keywords:

chronic alcoholic liver disease, morphometric analysis, quercetin, L-arginine-L-glutamate

Abstract

This article contains data about morphometric parameters of studies liver tissue in rats of different age periods females with chronic alcoholic liver disease and on the background of pathogenetic correction using quercetin and L-arginine-L-glutamate in the experimental conditions. Results showed that chronic alcoholic liver disease accompanied by morphometric changes of the hepatocytes’ diameter and their nuclei, nuclear-cytoplasmic ratio, stromal-parenchymatous ratio, the related volume of damaged hepatocytes and related volume of dual-core hepatocytes. According to morphometry, the biggest changes undergone liver parenchyma in immature and old animals. More pronounced hepatoprotective effect on the structure of the liver showing L-arginine L-glutamate, which is confirmed by the presence of a number of strong direct correlation.

Author Biography

L. O. Yarovenko, National Pirogov Memorial Medical University

кафедра патофізіології, ст.лаборант

References

References 1. Avtandilov G.G. 2002, «Fundamentals of quantitative pathological anatomy», Medicine, 240 p. (in Russian)

2004, «Scoring System assessment of morphological changes of the liver in chronic hepatitis», RZHGK, № 2, рр.4-8. (in Russian)

Gerashchenko S.B., Dyeltsova A.I., Zaharych A.D. 2011, «The value of computer morphometry in the diagnosis of chronic hepatitis with cholestasis syndrome», Bulletin problems of biology and medicine, Vol. 2, № 2, рр. 52-55. (in Ukrainian)

Hnatiuk M.S., Prishlyak A.M. 2005, «Morphological and functional features of the secretory activity of myocardial toxic lesions», Neuroendocrinology, рр. 148-150. (in Russian)

Kovalev G.A., Petrenko А.Y. 2004, «Еxperimental model of alcoholic liver injury in female rats // Vіsn. Hark. Nat. Unіv., № 617, рр. 15 -18. . (in Russian)

Sorochinnikov A.G., Dorosevich A.E. 1997, «Histological and microscopic machinery», Medicine, 448 p. (in Russian)

Published

2016-02-04

Issue

Section

Pharmacology and biochemistry