Synthesis and biological activity of derivatives of 2-((4-(piperidine-1-yl)phenyl)amino)-2-oxoethyl 4-piperazine-1-carbodithioate

Authors

  • T. A. Suleymanov Anadolu University, Turkey
  • Yusuf Ozkay Anadolu University, Turkey
  • C. Y. Shukurov Azerbaijan Medical University, Azerbaijan

DOI:

https://doi.org/10.24959/ubphj.16.9

Keywords:

dithiocarbamates, derivatives of piperazine-1-dithiocarbamate, antifungal, 4-aniline piperidine

Abstract

Derivatives of piperazin-1-dithiocarbamates 4-aniline piperidine were synthesized and their structures were identified by elemental analysis IR, NMR and mass spectroscopy. The biological activity of the synthesized derivatives of dithiocarbamates was investigated and was determined antifungal activity of substances E1 and E3. To study the antifungal activity of the synthesized compounds as test culture were used Candida albicans, Candida crusei and Candida parapsilosis.

Author Biography

C. Y. Shukurov, Azerbaijan Medical University

докторант кафедры фармацевтической химии, Азербайджанский медицинский университет

References

Seeman U., Bhaskar B., Muthiah R., Senthamaraikannan K. Synthesis, antimicrobial evaluation and QSAR studies of novel piperidin-4-yl-5-spiro-thiadiazoline derivatives // Bioorganic & Medicinal Chemistry Letters, 2010, 20, 6909–6914 p.

Prashanth M. K., Hosakere D. R., Lokanatha Rai K. M., Veeresh B. Synthesis, characterization, antidepressant and antioxidant activity of novel piperamides bearing piperidine and piperazine analogues // Bioorganic & Medicinal Chemistry Letters, 2012, 22, 7065–7070 p.

Zhigan J., Julin G., Chen W. et al. Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains // European Journal of Medicinal Chemistry, 2014, 82, 490-497 p.

Menezes D.C., Vieira F.T., Lima G.M. et al. Tin (IV) complexes of pyrrolidinedithiocarbamate: synthesis, characterisation and antifungal activity // European Journal of Medicinal Chemistry, 2005, 40, 1277–1282 p.

Yan Z., Shichong Yu, Renwu Li et al. Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl) propyl dithiocarbamates // European Journal of Medicinal Chemistry, 2014, 74, 366-374 p.

Madkour H. M. F., Farag A. A., Ramses S. Sh. and Ibrahiem N. A. A. Synthesis and Fungicidal Activity of New Imidazoles from 2-(Chloromethyl)-1H-benzimidazole // Phosphorus, Sulfur, and Silicon, 2006, 181, 255–265 p.

Ayşegül Gölcü. Transition metal complexes of propranolol dithiocarbamate: synthesis, characterization, analytical properties and biological activity // Transition Metal Chemistry, 2006, 31, 405–412 p.

Сулейманов Т.А., Юсуф Озкай, Шукюров Ч.Я. Синтез и биологическая активность производных 4-бензилпиперазин-1-дитиокарбаматов // Азербайджанский Фармацевтический и Фармакотерапевтический Журнал, -2014, -№2, -С. 10-14.

Сулейманов Т.А., Юсуф Озкай, Шукюров Ч.Я. Синтез и биологическая активность производных пиперазин-1-дитиокарбамата с морфолин анилином // Азербайджанский Фармацевтический и Фармакотерапевтический Журнал, -2015, -№1, -С.11-16.

Published

2016-02-04

Issue

Section

Pharmaceutical chemistry and pharmacognosy