Drying method influence on cranberry fruit phytosubstances microbiological activity

Authors

  • K. Yatsiuk Ivano-Frankivsk National Medical University, Ukraine
  • I. Fedorovska Ivano-Frankivsk National Medical University, Ukraine
  • R. Kutsyk Ivano-Frankivsk National Medical University, Ukraine

DOI:

https://doi.org/10.24959/ubphj.18.186

Keywords:

cranberry fruit, phytosubstances, microbiological research

Abstract

Topicality. Infectious diseases of the urinary system (IDUS) are one of the most widespread pathologies of the genitourinary system in women. Basic medicines for the treatment of IDUS are antibiotics. However, their widespread use causes a number of adverse drug reactions. Therefore, the actual issues of pharmaceutical practice are the search for more safe drugs based on biologically active substances contained in the medicinal plant raw material.

Aim. Study of pomace antimicrobial properties obtained from cranberry fruits that was subjected to different drying methods.

Materials and methods. The clinical test-strains of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, isolated from patients with urological infections were used in the experiment. Antimicrobial properties of the received samples were studied by agar diffusion. The results were evaluated by the diameter of growth zones retardation of microorganisms’ test cultures.

Results and discussion. Cranberry fruit pomace showed antimicrobial activity against the most widespread uropathogenic microorganisms: S. aureus, Bacillus subtils, E. coli and antifungal action against Candida albicans. The widest spectrum of antimicrobial activity revealed pomace samples that was dried in a drying cabinet.

Conclusions. Considering the obtained results, cranberry fruit pomace can be recommended for the further medicines creation for the prevention and treatment of urinary system infections.

Author Biographies

K. Yatsiuk, Ivano-Frankivsk National Medical University

Assistant Department of organization and economy of pharmacy and drug technology

I. Fedorovska, Ivano-Frankivsk National Medical University

Doctor of Philosophy in Pharmaceutical Sciences, Associate Professor Department of Organization and Economy
of Pharmacy and drug technology

R. Kutsyk, Ivano-Frankivsk National Medical University

Doctor in Sciences of Medicine, professor, head of Department of microbiology, virology and immunology

References

Nakaz MOZ Ukrainy № 816 vіd 23.11.11 r. (2011). «Unіfіkovanyi klіnіchnyi protokol medychnoi dopomohy. Hostryi neuskladnenyi tsystyt u zhіnok».

Guay, D. R. P. (2009). Cranberry and Urinary Tract Infections. Drugs, 69 (7), 775–807. https://doi.org/10.2165/00003495-200969070-00002

LaPlante, K. L., Sarkisian, S. A., Woodmansee, S., Rowley, D. C., & Seeram, N. P. (2012). Effects of Cranberry Extracts on Growth and Biofilm Production of Escherichia coli and Staphylococcus species. Phytotherapy Research, 26 (9), 1371–1374. https://doi.org/10.1002/ptr.4592

Davidson, E., Zimmermann, B. F., Jungfer, E., & Chrubasik-Hausmann, S. (2013). Prevention of Urinary Tract Infections withVacciniumProducts. Phytotherapy Research, 28 (3), 465–470. https://doi.org/10.1002/ptr.5047

Ulrey, R. K., Barksdale, S. M., Zhou, W., & van Hoek, M. L. (2014). Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa. BMC Complementary and Alternative Medicine, 14 (1). https://doi.org/10.1186/1472-6882-14-499

Patel, K. D., Scarano, F. J., Kondo, M., Hurta, R. A. R., & Neto, C. C. (2011). Proanthocyanidin-rich Extracts from Cranberry Fruit (Vaccinium macrocarpon Ait.) Selectively Inhibit the Growth of Human Pathogenic Fungi Candida spp. and Cryptococcus neoformans. Journal of Agricultural and Food Chemistry, 59 (24), 12864–12873. https://doi.org/10.1021/jf2035466

Nastanova Yevropeiskoi asotsіatsіi urolohіv іz lіkuvannia іnfektsіi sechovykh shliakhіv (2013). EAU, 2012/2013.

Derzhavne pidpryiemstvo «Ukrainskyi naukovyi ekspertnyi farmakopeinyi tsentr yakosti likarskykh zasobiv». (2008) Derzhavna farmakopeia Ukrainy. (Vols 1–3 vol.2). (2-e ed.) Kharkiv, 280.

Bergey, D. H, Holt, J. G. (eds). (1997). Bergey’s manual of systematic bacteriology (Vol. 1-2, 9-editions). Moscow: Mir, 553–559.

Downloads

Published

2018-12-05

Issue

No. 4(57) (2018)

Section

Microbiological research

License

Copyright (c) 2018 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).