Drying method influence on cranberry fruit phytosubstances microbiological activity

K. Yatsiuk, I. Fedorovska, R. Kutsyk


Topicality. Infectious diseases of the urinary system (IDUS) are one of the most widespread pathologies of the genitourinary system in women. Basic medicines for the treatment of IDUS are antibiotics. However, their widespread use causes a number of adverse drug reactions. Therefore, the actual issues of pharmaceutical practice are the search for more safe drugs based on biologically active substances contained in the medicinal plant raw material.

Aim. Study of pomace antimicrobial properties obtained from cranberry fruits that was subjected to different drying methods.

Materials and methods. The clinical test-strains of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, isolated from patients with urological infections were used in the experiment. Antimicrobial properties of the received samples were studied by agar diffusion. The results were evaluated by the diameter of growth zones retardation of microorganisms’ test cultures.

Results and discussion. Cranberry fruit pomace showed antimicrobial activity against the most widespread uropathogenic microorganisms: S. aureus, Bacillus subtils, E. coli and antifungal action against Candida albicans. The widest spectrum of antimicrobial activity revealed pomace samples that was dried in a drying cabinet.

Conclusions. Considering the obtained results, cranberry fruit pomace can be recommended for the further medicines creation for the prevention and treatment of urinary system infections.


cranberry fruit; phytosubstances; microbiological research


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3. Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species / K. L. LaPlante, S. A. Sarkisian, S. Woodmansee et al. // Phytother. Res. – 2012. – Vol. 26, № 9. – P. 1371–1374.

4. Prevention of urinary tract infections with vaccinium products. / E. Davidson, B. F. Zimmermann, E. Jungfer, S. Chrubasik-Hausmann // Phytother. Res. –2014. – Vol. 28, № 3. – P. 465–470.

5. Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa / R. K. Ulrey, S. M. Barksdale, W. Zhou, M. L. van Hoek // BMC Complement. Altern. Med. – 2014. – Vol. 14, (1).

6. Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) selectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans / K. D. Patel, F. J. Scarano, M. Kondo et al. // J. Agric. Food. Chem. – 2011. – Vol. 59, № 24. – P. 12864–12873.

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Abbreviated key title: Ukr. bìofarm. ž.

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