Biopharmaceutical choice justification of basis for dermatological ointment
DOI:
https://doi.org/10.24959/ubphj.18.190Keywords:
biopharmaceutical studies, extemporally ointments, emulsion ointment basesAbstract
Topicality. In the extemporal ointments manufactured in Ukraine, vaseline or a mixture of lanolin with vaseline are used as a base. The prospect of the extemporal prescription encourages the improvement of the outdated foundations, which will allow a more complete release of the active ingredients and minimize their negative impact on the physiological state of the skin.
Aim. To study nature and composition influence of bases on the dynamics of medicinal substances release and the antimicrobial activity of an ointment with boric and salicylic acid.
Materials and methods. The dynamics of medicinal substances release was studied by equilibrium dialysis through a semipermeable membrane of the ointment with 5 % boric acid and 20 % salicylic acid, which are made on the different bases. The antimicrobial activity of ointment samples was studied in vitro conditions by the diffusion into agar standard in microbiological practice in the modification of wells.
Results and discussion. A comparative analysis of the dynamics of medicinal substances release and antimicrobial activity of the samples showed a dependence on the nature and composition of the bases. The most degree of release of medicinal substances and antimicrobial activity was detected in samples on an emulsion basis compared with fat.
Conclusions. The results are indicate obtained the dependence of dynamics of medicinal substances release and antibacterial activity on the nature and composition of the base and allow us to recommend the emulsion bases for salicylic and boric ointments.
References
Zuikina, E. V. Polovko, N. P. (2017). Suchasni dosiahnennia farmatsevtychnoi tekhnolohii i biotekhnolohii, 3, 110–113. Kharkiv: NFaU.
Shmatenko, V. (2014). Substantiation of the base composition with the purpose of creation of a soft dosage form for treating a wound process. Vìsnik farmacìï, 2 (78), 20–24. https://doi.org/10.24959/nphj.14.1960
Zuykina, E. V., Polovko, N. P. (2018). Suchasni dosiahnennia farmatsevtychnoi tekhnolohii i biotekhnolohii, 4, 93. Kharkiv: NFaU.
Gusarov, V. I., Polovko, N. P., Gubar, S. M., Kovalenko, S. M., Strus, O. Ye. (2012). Ukraïns’kij bìofarmacevtičnij žurnal, 17 (1), 35–39.
Khalavka, M. V., Ruban, O. A., Pulyaev, D. S., Hrudko, K. V. (2014) Biopharmaceutical research on the selection of base for «Glytacyd» ointment Ukraïns’kij bìofarmacevtičnij žurnal, 32 (3), 8–11.
Markiv, V. I., Bavykina, M. L., Vishnevskaya, L. I. (2014). Farmatcevticheskii klaster kak integratciia nauki, obrazovaniia i proizvodstva: mezhdunarodnaia nauchno–prakticheskaia konferentciia (9-16. 04. 2014). Belgorod, 98–100.
Kovaleva, T. M., Polovko, N. P. (2013). Problemy ekolohichnoi ta medychnoi henetyky i klinichnoi imunolohii, 2, 222–229.
Derzhavne pidpryiemstvo «Ukrainskyi naukovyi ekspertnyi farmakopeinyi tsentr yakosti likarskykh zasobiv». (2015) Derzhavna farmakopeia Ukrainy. (Vols 1–3 vol. 1). (2-e ed.) Kharkiv, 1128.
Volyansky, Yu. L., Gritsenko, I. S., Shirobokov, V. P. (2004). Vyvchennia spetsyfichnoi aktyvnosti protymikrobnykh likarskykh zasobiv. Kyiv, 38.
Romagnin, D. M. Berdey, I. I., Gladyshev, V. V., Lisyansky, G. P. (2016). Farmatsevtychnyi zhurnal, 5, 37–42.
Downloads
Published
Issue
Section
License
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
