Study of the nasal gel’s “Phytorin-plus” stability for the treatment of viral rhinitis




nasal gel, viral rhinitis, stability, shelf life, storage conditions


Topicality. In order to treat viral rhinitis effectively, it is actual to create new nasal gels with a complex antiviral and antimicrobial action. The nasal gel under the conventional name “Phytorin-plus” with the content of dry licorice root extract, essential oils of eucalyptus and pine for the treatment of this pathology was developed at the Technology of Drugs Department of the NUPh. 

Aim. To investigate the stability, establish the shelf life and storage conditions of the proposed gel.

Materials and methods. The study subjects were five series of samples of nasal gel “Phytorin-plus”. In accordance with the requirements of the State Pharmacopoeia of Ukraine, the quality control of the medicine was carried out according to the indicators: description, homogeneity, identification and quantitative determination of active ingredients, pH value, microbiological purity, weight of the contents of the package. Rheological properties were studied on a viscometer BROOKFIELD DV-II + PRO (USA).

Results and discussion. Based on the complex of physical, chemical and structural-mechanical researches, the shelf life and storage conditions of the nasal gel were determined for 2 years in aluminum tubes at a temperature of (8-15) °C and/or (15-25) °C. It has been shown that gel “Phytorin-plus” is a structured system with certain thixotropic properties. Calculated parameters of mechanical stability and coefficients of dynamic dilution of samples of the medicine confirm its stability in the process of storage.

Conclusions. The stability of the nasal gel has been “Phytorin-plus” was experimentally studied, its shelf life and storage conditions have been determined.

Author Biographies

O. Rukhmakova, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Associate Professor of Technology of Drugs Department

I. Karpenko, National University of Pharmacy

postgraduate student Technology of Drugs Department

T. Yarnykh, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor, Head of Technology of Drugs Department


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Biopharmaceutical research