Study of the drug “Arthritan” acute toxicity




“Artritan”, acute toxicity, rats, safety of use


Topicality. To ensure the modern herbal medicine integration into the healthcare system is one of the tasks for modern scientific and practical medical community. Therefore, today the actual problem in medical and pharmaceutical industry is  production of high-quality plant origin products in order to meet the needs of  our country population.

Aim. Experimental study of drug “Arthritan” toxicological properties in the context of acute toxicity modeling to justify the safety use in clinical practice.

Materials and methods. The study was performed according to the method of V. B. Prozorovsky with intragastric administration in rats with the dose range of 1.0-5.0 ml/kg. Throughout the study (14 days), observations were made in survival of experimental animals, manifestations of intoxication, and the dynamics of the individual symptoms development.

Results and discussion. Under the conditions of single intragastric administration in rats, the drug “Arthritan” in the dose range of 1.0-5.0 ml/kg did not have a toxic effect on the general condition and  animals behavior, did not cause their death. This allowed us to assume that with this route of administration, the LD50 of the investigational drug exceeds 5.0 ml/kg. The obtained LD50 values allow it to be attributed to the studied route of administration according to the generally accepted classification of K.K. Sidorov to the V toxicity class – practically non-toxic substances.

Conclusions. According the toxicological characteristics «Arthritan» drug is practically non-toxic to the human body, which determines the prospects for its further study with the aim of application in clinical practice.

Author Biographies

Yu. Naboka, National University of Pharmacy

postgraduate student, of the Department of Clinical Pharmacology and Clinical Pharmacy

N. Zubitska, General Director, LLC “Zelena Planeta Zemnoi”

генеральний директор

I. Zupanets, National University of Pharmacy

Doctor of Medicine, professor, head of the Department of Clinical Pharmacology and Clinical Pharmacy

S. Shebeko, National University of Pharmacy

PhD in Pharmacy, associate professor of the Department of Clinical Pharmacology and Clinical Pharmacy

I. Otrishko, National University of Pharmacy

PhD in Pharmacy, associate professor of the Department of Clinical Pharmacology and Clinical Pharmacy


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Pharmacology and biochemistry