DOI: https://doi.org/10.24959/ubphj.18.195

The effect of the third-generation aromatase inhibitors on eating behavior in experimental metabolic syndrome

D. Lytkin

Abstract


Topicality. In recent years, the increasing attention has been paid to the role of peripheral aromatase reaction enhancement in the pathogenesis of metabolic syndrome. The associated hormonal regulation disorder are able to affect not only the carbohydrate and lipid metabolism but also the patients eating behavior.

Aim. Study the influence of third-generation aromatase inhibitors on eating behavior and serum leptin content in hamsters with experimental metabolic syndrome.

Materials and methods. The study was carried out on the model of experimental diet induced metabolic syndrome in hamsters. To assess food behavior, the number of meals and meal time of animals were recorded. The serum leptin content was determined by the immune enzyme method.

Results and discussion. Tested aromatase inhibitors led to a significant decrease in the number of meals, meal time and serum leptin content in the studied animals of different age and sex. In most cases, the highest effect was demonstrated by letrozole at a dose of 0.309 mg/kg.

Conclusions. Third-generation aromatase inhibitors are able to reduce manifestations of hyperphagia and leptin resistance in the conditions of metabolic syndrome.


Keywords


exemestane; letrozole; anastrozole; leptin resistance; hyperphagia

References


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GOST Style Citations


1. Kim, C. Endogenous sex hormones, metabolic syndrome, and diabetes in men and women / C. Kim, J. B. Halter // Current Cardiol. Reports. – 2014. – № 16 (4). – P. 476. https://doi.org/10.1007/s11886-014-0467-6

2. Banks, W. A. Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity / W. A. Banks // Current Pharmac. Design. – 2001. – № 7 (2). – P. 125–133. https://doi.org/10.2174/1381612013398310

3. Lytkin, D. V. The effect of third-generation aromatase inhibitors on aromatase activity in visceral adipose tissue / D. V. Lytkin, A. L. Zagayko, T. O. Briukhanova // Regulatory Mechanisms in Biosystems. – 2018. – № 9 (2). – P. 209–215. https://doi.org/10.15421/021831

4. Short-term aromatase inhibition: effects on glucose metabolism and serum leptin levels in young and elderly men / B. Lapauw, G. T’Sjoen, A. Mahmoud et al. // Eur. J. of Endocrinol. – 2009. – № 160 (3). – P. 397–402. https://doi.org/10.1530/eje-08-0881

5. The high-fat high-fructose hamster as an animal model for niacin’s biological activities in humans / B. A. Connolly, D. P. O’Connell, S. Lamon-Fava et al. // Metabolism. – 2013. – № 62 (12). – P. 1840–1849. https://doi.org/10.1016/j.metabol.2013.08.001

6. Animal models of metabolic syndrome: a review / S. K. Wong, K.-Y. Chin, F. H. Suhaimi et al. // Nutrition & Metabolism. – 2016. – № 13 (1). – P. 65. http://doi.org/10.1186/s12986-016-0123-9

7. Nair, A. B. A simple practice guide for dose conversion between animals and human / A. B. Nair, S. Jacob // J. of Basic and Clin. Pharmacy. – 2016. – № 7 (2). – P. 27–31. https://doi.org/10.4103/0976-0105.177703

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Abbreviated key title: Ukr. bìofarm. ž.

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