The effect of the third-generation aromatase inhibitors on eating behavior in experimental metabolic syndrome
Keywords:exemestane, letrozole, anastrozole, leptin resistance, hyperphagia
Topicality. In recent years, the increasing attention has been paid to the role of peripheral aromatase reaction enhancement in the pathogenesis of metabolic syndrome. The associated hormonal regulation disorder are able to affect not only the carbohydrate and lipid metabolism but also the patients eating behavior.
Aim. Study the influence of third-generation aromatase inhibitors on eating behavior and serum leptin content in hamsters with experimental metabolic syndrome.
Materials and methods. The study was carried out on the model of experimental diet induced metabolic syndrome in hamsters. To assess food behavior, the number of meals and meal time of animals were recorded. The serum leptin content was determined by the immune enzyme method.
Results and discussion. Tested aromatase inhibitors led to a significant decrease in the number of meals, meal time and serum leptin content in the studied animals of different age and sex. In most cases, the highest effect was demonstrated by letrozole at a dose of 0.309 mg/kg.
Conclusions. Third-generation aromatase inhibitors are able to reduce manifestations of hyperphagia and leptin resistance in the conditions of metabolic syndrome.
Kim, C., & Halter, J. B. (2014). Endogenous Sex Hormones, Metabolic Syndrome, and Diabetes in Men and Women. Current Cardiology Reports, 16 (4), 467. https://doi.org/10.1007/s11886-014-0467-6
Banks, B. S. P. (2001). Leptin Transport Across the Blood-Brain Barrier: Implications for the Cause and Treatment of Obesity. Current Pharmaceutical Design, 7 (2), 125–133. https://doi.org/10.2174/1381612013398310
Lytkin, D. V., Zagayko, A. L., & Briukhanova, T. O. (2018). The effect of third-generation aromatase inhibitors on aromatase avtivity in visceral adipose tissue. Regulatory Mechanisms in Biosystems, 9 (2), 209–215. https://doi.org/10.15421/021831
Lapauw, B., T’Sjoen, G., Mahmoud, A., Kaufman, J. M., & Ruige, J. B. (2009). Short-term aromatase inhibition: effects on glucose metabolism and serum leptin levels in young and elderly men. European Journal of Endocrinology, 160 (3), 397–402. https://doi.org/10.1530/eje-08-0881
Connolly, B. A., O’Connell, D. P., Lamon-Fava, S., LeBlanc, D. F., Kuang, Y.-L., Schaefer, E. J., … Bachovchin, W. W. (2013). The high-fat high-fructose hamster as an animal model for niacin’s biological activities in humans. Metabolism, 62 (12), 1840–1849. https://doi.org/10.1016/j.metabol.2013.08.001
Wong, S. K., Chin, K.-Y., Suhaimi, F. H., Fairus, A., Ima-Nirwana, S. (2016). Animal models of metabolic syndrome: a review. Nutrition & Metabolism, 13 (1), 65. http://doi.org/10.1186/s12986-016-0123-9
Nair, A., & Jacob, S. (2016). A simple practice guide for dose conversion between animals and human. Journal of Basic and Clinical Pharmacy, 7 (2), 27. https://doi.org/10.4103/0976-0105.177703
Gattermann, R., Johnston, R. E., Yigit, N., Fritzsche, P., Larimer, S., Ozkurt, S., … McPhee, M. E. (2008). Golden hamsters are nocturnal in captivity but diurnal in nature. Biology Letters, 4 (3), 253–255. https://doi.org/10.1098/rsbl.2008.0066
Rebrova, O. U. (2006). Statisticheskii analiz meditcinskikh dannykh. Primenenie paketa prikladnykh programm STATISTICA. Moscow: MediaSphere, 312.
Copyright (c) 2018 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).