The effect of the third-generation aromatase inhibitors on eating behavior in experimental metabolic syndrome




exemestane, letrozole, anastrozole, leptin resistance, hyperphagia


Topicality. In recent years, the increasing attention has been paid to the role of peripheral aromatase reaction enhancement in the pathogenesis of metabolic syndrome. The associated hormonal regulation disorder are able to affect not only the carbohydrate and lipid metabolism but also the patients eating behavior.

Aim. Study the influence of third-generation aromatase inhibitors on eating behavior and serum leptin content in hamsters with experimental metabolic syndrome.

Materials and methods. The study was carried out on the model of experimental diet induced metabolic syndrome in hamsters. To assess food behavior, the number of meals and meal time of animals were recorded. The serum leptin content was determined by the immune enzyme method.

Results and discussion. Tested aromatase inhibitors led to a significant decrease in the number of meals, meal time and serum leptin content in the studied animals of different age and sex. In most cases, the highest effect was demonstrated by letrozole at a dose of 0.309 mg/kg.

Conclusions. Third-generation aromatase inhibitors are able to reduce manifestations of hyperphagia and leptin resistance in the conditions of metabolic syndrome.

Author Biography

D. Lytkin, National University of Pharmacy

assistant of the biological chemistry department


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Pharmacology and biochemistry