Substantiation of auxiliary substances of in the composition of tablets with dry extract of zingiber officinale

Authors

DOI:

https://doi.org/10.24959/ubphj.19.233

Keywords:

type II diabetes, dry ginger extract, Excipients, tablets, direct pressing, pharmacotechnological indicators of powder masses and tablets, mathematical planning of the experiment, three-factor analysis of varianc

Abstract

Topicality. Due to its rich chemical composition and pharmacological activity, Zingiber officinale is a promising raw material for creating various drugs, including ones for the treatment of type 2 diabetes.
Aim. To obtain tablets with dry ginger extract by direct pressing using polyfactorial dispersion analysis (taking into account the quality factors).
Materials and methods. The objects of the study were dry ginger extract, filler – Galen IQ 721 and excipients of three technological groups: dry binders, moisture regulators and lubricants. The effect of auxiliary substances on such indicators as bulk density, tapped density and the Carr index of the tablet mass, as well as disintegration, mechanical strength and friability of the obtained tablets have been investigated.
Results and discussion. Using the mathematical planning of the experiment by the 3 × 3 Latin square method, the influence of qualitative factors on the pharmacological indicators of tablets with a dry extract of ginger has been studied.
Conclusions. According to the results of analysis of variance, the optimal excipients in the composition of tablets with ginger extract were chosen: from the group of binders – Kollidone k30, as a moisture regulator – Neusilin UFL 2 and lubricant – calcium stearate.

Author Biographies

Walid Ahmad Alkhalaf Malek, National University of Pharmacy

post graduate student of the Department of Industrial Technology of Drugs

O. A. Ruban, National University of Pharmacy

Doctor of Pharmacy, Professor, head of the Department of Industrial Technology of Drugs

O. V. Kutova, National University of Pharmacy

Candidate of Technical Sciences, Associate Professor of the Department of Processes and Equipment of Chemical
and Pharmaceutical Production

N. A. Gerbina, National University of Pharmacy

канд. фармац. наук, доцент кафедры заводской технологии лекарств

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Published

2019-09-02

Issue

No. 3(60) (2019)

Section

Biopharmaceutical research

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