DOI: https://doi.org/10.24959/170227

The modern state of orally disintegrating tablets development

I. V. Zupanets, O. A. Ruban, T. E. Kolisnyk

Abstract


Topicality. Orally disintegrating tablets (hereinafter ODT) represent the modern direction of solid dosage form development. Due to the rapid disintegration in a small amount of liquid, ODT are characterized by better bioavailability, ease of use and less toxic effects of active pharmaceutical ingredients (API) on the liver owing to reducing the first-pass metabolism.
Aim. To analyze literary sources regarding the current state of pharmaceutical development of this dosage form.
Materials and methods. Analysis of scientific bases of literary sources such as: PubMed, ResearchGate, Academia. edu, Scopus, etc.
Results and discussion. The development of drugs in the form of ODT suggests taking into account certain requirements for this dosage form: sufficient mechanical strength along with rapid disintegration in a small amount of liquid, pleasant tactile and taste sensations, the choice of optimal packaging. The achievement of the optimal strength and disintegration is possible by using two methods – adding excipients (first of all, fillers, binders and superdisintegrators) and selecting the pressure on a tablet machine. Satisfactory tactile and taste sensations of the ODT are provided by masking the taste of API through addition of flavors, taste correctives and physical and chemical methods. The choice of one or another type and material of the packaging is determined by the physical and chemical properties of the API.
Conclusions. Despite the fact that ODT drugs belong to tableted dosage forms, they have certain specific differences from traditional tablets. Therefore, their pharmaceutical development involves especial approaches and tests that are necessary for the successful realization of this dosage form advantages


Keywords


orally disintegrating tablets; pharmaceutical development; taste masking; disintegration

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