Study of antimicrobial preservative efficiency in gels with Sapropel extract

Authors

DOI:

https://doi.org/10.24959/ubphj.19.240

Keywords:

gel, sapropel extract, preservative, the effectiveness of preservatives

Abstract

Topicality. Providing stability during the storage and microbiological purity is a compulsory condition to guarantee the quality of medicine.
Aim. To substantiate the selection of preservative in the development of a stable gel with sapropel extract.
Materials and methods. The objects of the study were gels with sapropel extract and a number of preservatives. In researches the evaluating methodology of antimicrobial preservatives effectiveness, according to the SPhU 2.0 used.

Results and discussion. Microbiological studies have confirmed the different intensities of selected preservative action in the medium-effective concentration: nipagin, benzoate sodium and potassium sorbate. The local action of the developed gel with sapropel extrac was established. It is required to introducе additional preservative into gel composition.

Conclusions. On the basis of the conducted microbiological researches, the introduction of potassium sorbate at a concentration of  0.2 % as a preservative for the composition of gel with sapropel extract was substantiated.

Author Biographies

O. Strus, Danylo Halytsky Lviv National Medical University

Candidate of Pharmacy (Ph.D.), associate professor of the Department of Drug Technology and Biopharmaceutics

N. Polovko, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor of the Department of Drug Technology

L. Strelnikov, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor of the Department of Biotechnology

References

Vu, N., Lou, R. J., Kupiec, T. C. (2014). Quality Control: Microbial Limit Tests for Nonsterile Pharmaceuticals, Part 2. International Journal of Pharmaceutical Compounding, 18 (4), 305–310.

Fedorovskaia, M. I., Kutcik, R. V., Polovko, N. P. (2017). Vestnik Tadzhikskogo natcionalnogo universiteta. Seriia estestvennykh nauk, 1, 200–204.

Himoudy, I. (2016). Preservatives and their role in Pharma and Clinical Research. International Journal of Pharma Sciences and Scientific Research, 2 (4), 134–151. https://doi.org/10.25141/2471-6782-2016-4.0134

Strus, O. Ye., Polovko, N. P., Maloshtan, L. M., Yatsenko, E. Yu. (2014). Zbirnyk naukovykh prats spivrobitnykiv NMAPO imeni P. L. Shupyka, 23 (4), 392–398. Kyiv.

Derzhavna Farmakopeya Ukraїni: (Vols. 1–3). (2015). Derzhavne pіdprimstvo “Ukraїns’kij naukovij farmakopejnij centr yakostі lіkars’kih zasobіv”. (2-edition). Kharkiv : Derzhavne pіdprimstvo “Ukraїns’kij naukovij farmakopejnij centr yakostі lіkars’kih zasobіv”, 1, 1128.

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Published

2019-11-19

Issue

No. 4(61) (2019)

Section

Biopharmaceutical research

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Copyright (c) 2019 National University of Pharmacy

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