The study of physicochemical and pharmacotechnological properties of active substances in the composition of sublingual tablets
Keywords:stress, sublingual tablets, pharmacotechnological studies
Topicality. Every year there is new evidence of stress effect on everyday life and, as a consequence, the development of systemic diseases (atherosclerosis, coronary heart disease, pathological insomnia), therefore, the creation of an original combination drug for its prevention is a relevant task today.
Aim. To conduct pharmacotechnological and physico-chemical studies of active pharmaceutical ingredients (API) to select the optimal technology for the production of sublingual tablets.
Materials and methods. Glycine and magnesium citrate were chosen as the API, pharmacotechnological and physicchemical studies of which were carried out in accordance with the requirements of the State Pharmacopoeia of Ukraine.
Results and discussion. Crystallographic studies showed a significant difference in the form factor between glycine and magnesium citrate (0.49 and 0.18, respectively). Both APIs are non-hygroscopic, but magnesium citrate has better flowability (8.48 s/100 g) as opposed to glycine (40.52 s/100 g). The particle size distribution of API was studied (glycine is almost evenly distributed between No. 0, No. 0.1 and No. 0.5 sieves, magnesium citrate is sieved through No. 0 sieve).
Conclusions. Based on the results of the studies, the difference in the main technological characteristics of glycine and magnesium citrate is determined. In this regard, there is a need to choose excipients for the production of sublingual tablets by method of direct compression.
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