DOI: https://doi.org/10.24959/ubphj.19.247

Research of antiexcudative activity of the dry extracts of Iris hungarica leaves and rhizomes

G. Kerimova, A. Krechun, V. Rybak, O. Mykhailenko, V. Kovalev

Abstract


Topicality. Medicinal plants have a wide range of pharmacological activity due to, in particular, the presence of phenolic compounds. Such plant is representative of the genus Iris (Iridaceae) – Iris hungarica Waldst et Kit.
Aim. To investigate the anti-inflammatory activity of dry extracts from the Iris hungarica leaves and rhizomes using a model of carregenic edema in rats.
Materials and methods. The objects of study were the dry extracts of Iris hungarica leaves and rhizomes at a dose of 150 mg/kg. The antiexudative activity of the extracts was studied in a model of carrageenan inflammation in rats. Sodium diclofenac at a dose of 8 mg/kg and altan at a dose of 5 mg/kg were used as comparison drugs.
Results and discussion. The studied samples of extracts of Iris hungarica leaves and rhizomes had a inhibitory effect on the development of edema compared with control pathology, the antiexudative activity was 32.6 % and 41.6 %, respectively, which is quite high.
Conclusions. The dry extract of Iris hungarica rhizomes had the most pronounced antiexudative activity, which is approaching the activity (41.6 %) to the synthetic sodium diclofenac comparison preparation (48.4 %) and slightly exceeded the effect of the herbal drug altan (39.3 %).


Keywords


antiexcudative activity; dry extracts; Iris hungarica; sodium diclofenac; altan

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Abbreviated key title: Ukr. biopharm. j.

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