Research of antiexcudative activity of the dry extracts of Iris hungarica leaves and rhizomes

Authors

  • G. Kerimova National University of Pharmacy, Ukraine
  • A. Krechun National University of Pharmacy, Ukraine https://orcid.org/0000-0001-5545-9415
  • V. Rybak National University of Pharmacy, Ukraine
  • O. Mykhailenko National University of Pharmacy, Ukraine
  • V. Kovalev National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/ubphj.19.247

Keywords:

antiexcudative activity, dry extracts, Iris hungarica, sodium diclofenac, altan

Abstract

Topicality. Medicinal plants have a wide range of pharmacological activity due to, in particular, the presence of phenolic compounds. Such plant is representative of the genus Iris (Iridaceae) – Iris hungarica Waldst et Kit.
Aim. To investigate the anti-inflammatory activity of dry extracts from the Iris hungarica leaves and rhizomes using a model of carregenic edema in rats.
Materials and methods. The objects of study were the dry extracts of Iris hungarica leaves and rhizomes at a dose of 150 mg/kg. The antiexudative activity of the extracts was studied in a model of carrageenan inflammation in rats. Sodium diclofenac at a dose of 8 mg/kg and altan at a dose of 5 mg/kg were used as comparison drugs.
Results and discussion. The studied samples of extracts of Iris hungarica leaves and rhizomes had a inhibitory effect on the development of edema compared with control pathology, the antiexudative activity was 32.6 % and 41.6 %, respectively, which is quite high.
Conclusions. The dry extract of Iris hungarica rhizomes had the most pronounced antiexudative activity, which is approaching the activity (41.6 %) to the synthetic sodium diclofenac comparison preparation (48.4 %) and slightly exceeded the effect of the herbal drug altan (39.3 %).

Author Biographies

G. Kerimova, National University of Pharmacy

postgraduate student of the Department of Pathological Physiology

A. Krechun, National University of Pharmacy

postgraduate student of the Department of Pharmacognosy

V. Rybak, National University of Pharmacy

Doctor of Biological Sciences, Associate professor of the Department of Pathological Physiology

O. Mykhailenko, National University of Pharmacy

Candidate of Pharmaceutical Sciences, Assistant professor of the Department of Botany

V. Kovalev, National University of Pharmacy

Doctor of Pharmaceutical Sciences, Professor of the Department of Pharmacognosy

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Published

2019-11-19

Issue

Section

Pharmacology and biochemistry