Antidepressant activity of Calluna vulgaris L. (Hull.) herb extracts

Authors

DOI:

https://doi.org/10.24959/ubphj.20.249

Keywords:

Calluna vulgaris L., water and water-alcohol extracts, antidepressants, “Tail suspension test”, “Porsolt’s” test

Abstract

Topicality. Today, anxiety is becoming more urgent, due to the changes in social sphere, the intensity of life rhythm and other factors. Therefore, it is relevant to research new medicines based on medicinal herbal raw materials with anti-anxiety and antidepressant effects. The common heather (Calluna vulgaris (L.) Hull.) as a prospective species for the Ericaceae family, is also used in many countries as a source of sedative, anti-inflammatory and antimicrobial agents.
Aim. To investigate the water-alcohol and water extracts effect of heather grass on behavioral and emotional reactions in “Porsolt tests” and “Tail suspension test”.
Materials and methods. The antidepressant effect of Calluna vulgaris L. extracts in “Tail suspension test” and “Porsolt’s” test studied.
Results and discussion. In the “Tail suspension test” when the animals were administered with water-alcohol and water extracts, the total time of immobilization was reduced. The latent period of the first freezing during the introduction of water-alcohol extract was 1.25 times shorter than control. The latent period was longer in 1.14 times the control when the aqueous extract was administered. The total immobility at the administration of water-alcohol extract was the smallest (32.57 s). In the “Porsolt’s test” the water-alcohol extract of the Calluna vulgaris (L.) herb exhibits the highest antidepressant activity on the 1st and 3rd day of the experiment, as evidenced by the largest number of active swimming (190.29 s and 99.57 s) and the least time of immobilization (13.71 s and 15.14 s).
Conclusions. Passive swimming time during the administration of the water-alcohol extract of the Calluna vulgaris (L.) herb was the smallest on the 1st day of the experiment (156 s). It has been established that water and water-alcohol extracts of Calluna vulgaris L. herb have antidepressant effect and are superior in activity to St. John’s wort.

Author Biography

G. Starchenko, Ivano-Frankivsk National Medical University

Assistant of the Department of Pharmacy

References

Starchenko, G. Yu., Gritsik, A. R., Vinnik, M. I., Ivanochko, V. M. (2017). Patent 124993 Ukraine, Zasib z protytryvozhnoiu aktyvnistiu. МPК (2018.01), А61К 36/00, А61Р 25/00. № u 2017 11809.

Hrodzinskyi, A. M. (1990). Likarski roslyny: Entsyklopedychnyi dovidnyk. Kyiv, 544.

Monschein, M., Iglesias Neira, J., Kunert, O., & Bucar, F. (2009). Phytochemistry of heather (Calluna vulgaris (L.) Hull) and its altitudinal alteration. Phytochemistry Reviews, 9 (2), 205–215. https://doi.org/10.1007/s11101-009-9153-5

Rodrigues, F., Moreira, T., Pinto, D., Pimentel, F. B., Costa, A. S. G., Nunes, M. A., … Oliveira, M. B. P. P. (2018). The phytochemical and bioactivity profiles of wild Calluna vulgaris L. flowers. Food Research International, 111, 724–731. https://doi.org/10.1016/j.foodres.2018.06.012

Telishevska, H. Yu., Hrytsyk, A. R. (2012). Ukrainskyi visnyk psykhonevrolohii, 20 (2 (71)), 63–64.

Stefanov, A. (2001). Doklinichni doslidzhennia likarskykh zasobiv. Kyiv: Avicena, 334–339.

Romanenko, Ye. A., Koshovyi, O. M., Komisarenko, A. M., Shtryhol, S. Yu. (2015). Zbirnyk naukovykh prats spivrobitnykiv NMAPO imeni P. L. Shupyka, 24(5), 212–217.

Tsemenko, K., Kireyev, I., & Koshoviy, O. (2019). Evaluation of emotional-behavioral reactivity in rats after the introduction of cranberries common complex in combination with arginine. Ukrainian Biopharmaceutical Journal, 1 (58), 50–54. https://doi.org/10.24959/ubphj.19.210

Bondarenko, V. H., Kanivska, I. Yu., Paramonova, S. M. (2006). Teoriia ymovirnostei i matematychna statystyka, 1. Kyiv : NTUU “KPI”, 125.

Karkyshchenko, V. N., Kapanadze, H. D., Denhyna, S. E., Stankova, N. V. (2011). Byomedytsyna, 1, 72–74.

Gamma, T. V., Epishkin, I. V., Korenjuk, I. I., Ablaeva, U. D., Repetij, M. I., Husainov, D. R., Katjushina, O. V. (2009). Uchenye zapiski Tavricheskogo nacional’nogo universiteta im. V. I. Vernadskogo Serija «Biologija, himija», 22 ((61) 2), 16–23.

Mamylina, N. V., Janov, A. Ju. (2011). Sovremennaja medicina: aktual’nye voprosy: sbornik stattej po materialam ІІ mezhdunarodnoj nauchnoprakticheskoj konferencii. Novosibirsk : SibAK, 19–23.

Yan, H.-C., Cao, X., Das, M., Zhu, X.-H., & Gao, T.-M. (2010). Behavioral animal models of depression. Neuroscience Bulletin, 26 (4), 327–337. https://doi.org/10.1007/s12264-010-0323-7

Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978). Behavioural despair in rats: A new model sensitive to antidepressant treatments. European Journal of Pharmacology, 47 (4), 379–391. https://doi.org/10.1016/0014-2999(78)90118-8

Published

2020-03-02

Issue

Section

Pharmacology and biochemistry