Comparative research of the nephrotropic properties of modern non-steroidal anti-inflammatory drugs
DOI:
https://doi.org/10.24959/ubphj.20.259Keywords:
nephrotoxic effect, analgesic nephropathy, diclofenac sodium, indomethacin, piroxicam, meloxicam, celecoxibAbstract
Topicality. Recently, there has been a growing body of work on the nephroxicity of NSAIDs in the literature. The degree of impaired renal function on the background of NSAIDs varies from a slight increase in blood creatinine to anuria. It is known that most NSAIDs have nephrotoxic effects, but the extent of their negative effects on the kidneys is different.
Aim. To comparatively study the effect of the most commonly used NSAIDs of different generations on the functional status of the kidneys in experimental animals.
Materials and methods. Diclofenac sodium, piroxicam, indomethacin, meloxicam and celecocosib were selected for the comparative study. The state of the kidneys excretory function of intact animals was evaluated according to the following indicators: water diuresis (2 hours); urea, creatinine content in the blood and urine, the level of TBK-active products in the kidney homogenate. The kidney mass ratio and glomerular filtration rate were calculated.
Results and discussion. The administration of indomethacin to intact rats resulted in a significant impairment of renal functional status. Piroxicam also showed a pronounced, albeit less than indomethacin, nephrotoxic effect. Meloxicam and diclofenac sodium produced a moderate nephrotoxic effect. When celecoxib was used, functional impairment of kidneys was observed, but the changes were unreliable.
Conclusions. According to the level of nephrotoxicity comparable drugs can be arranged as follows: indomethacin > piroxicam > diclofenac = meloxicam > celecoxib.
References
Shchokina, K. H. (2006). Eksperymentalne obgruntuvannia ratsionalnoho vyboru suchasnykh i perspektyvnykh preparativ z protyzapalnoiu diieiu. Candidate’s thesis. Kharkiv, 202.
Bikkinina, G. M., Safuanov, A. R. (2015). Molodoi uchenyi, 7(87), 269–272.
Zhuravleva, M. V., Kukes, V. G., Prokofev, A. B., Serebrova, S. Iu., Gorodetckaia, G. I., Berdnikova, N. G. (2016). Mezhdunarodnyi zhurnal prikladnykh i fundamentalnykh issledovanii, 6-4, 687–696
Chichasova, N. V. (2006). Russkii medetcinskii zhurnal, 2, 215–217.
Galesic, K., Morovic-Vergles, J., Jelaković, B. (2005). Nonsteroidal antirheumatics and the kidney. Reumatizm, 52(2), 61–66.
Whelton, A. (1999). Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications. The American Journal of Medicine, 106(5), 13S–24S. https://doi.org/10.1016/s0002-9343(99)00113-8
Ravnskov, U. (1999). Glomerular, tubular and interstitial nephritis associated with non‐steroidal antiinflammatory drugs. Evidence of a common mechanism. British Journal of Clinical Pharmacology, 47(2), 203–210. https://doi.org/10.1046/j.1365-2125.1999.00869.x
Bennett, W. M., Porter, G. A. (1998). Analgesic nephropathy and the use of nonsteroidal anti-inflammatory drugs in renal patients: new insight. Journal of Nephrology, 11(2), 70–75.
Becker-Cohen, R., & Frishberg, Y. (2001). Severe reversible renal failure due to naproxen-associated acute interstitial nephritis. European Journal of Pediatrics, 160(5), 293–295. https://doi.org/10.1007/s004310100729
Schattner, A., Sokolovskaya, N., & Cohen, J. (2000). Fatal hepatitis and renal failure during treatment with nimesulide. Journal of Internal Medicine, 247(1), 153–155. https://doi.org/10.1046/j.1365-2796.2000.00612.x
Batiushin, M. M., Terentev, V. P., Dmitrieva, O. V., Povilaite, P. E. (2009). Khronicheskaia bolezn pochek: mesto nesteroidnykh protivovospalitelnykh preparatov. Elista: ZAO NPP «Dzhangar», 128.
Hickey, E., Raje, R., Reid, V., Gross, S., & Ray, S. (2001). Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. Free Radical Biology and Medicine, 31(2), 139–152. https://doi.org/10.1016/s0891-5849(01)00560-3
Galesic, K, Morovic-Vergles, J. (2003). Drug-induced acute interstitial nephritis. Reumatizm, 50(1), 14–17.
Krummel, T., Dimitrov, Y., Moulin, B., Hannedouche, T. (2000). Drug points: Acute renal failure induced by topical ketoprofen. BMJ, 320(7227), 93. https://doi.org/10.1136/bmj.320.7227.93
Ibeiez, L., Morlans, M., Vidal, X., Martanez, M. J., & Laporte, J.-R. (2005). Case-control study of regular analgesic and nonsteroidal anti-inflammatory use and end-stage renal disease. Kidney International, 67(6), 2393–2398. https://doi.org/10.1111/j.1523-1755.2005.00346.x
Revai, T., Harmos, G. (1999). Nephrotic syndrome and acute interstitial nephritis associated with the use of diclofenac. Wien Klin Wochenschr, 111(13), 523–524.
Rocha, J. L., & Fernández-Alonso, J. (2001). Acute tubulointerstitial nephritis associated with the selective COX-2 enzyme inhibitor, rofecoxib. The Lancet, 357(9272), 1946–1947. https://doi.org/10.1016/s0140-6736(00)05083-2
Joannidis, M. (2004). Drug-induced renal failure in the ICU. Int J Artif Organs., 12, 1034–1042.
Shtryhol, S. Yu., Lisovyi, V. M., Zupanets, I. A., Shebeko, S. K. (2009). Metody eksperymentalnoho modeliuvannia urazhennia nyrok dlia farmakolohichnykh doslidzhen: Metodychni rekomendatsii. Kyiv, 47.
Kamyshnikov, V. S. (2002). Spravochnik po klinichesko-biokhimicheskoi laboratornoi diagnostike: (Vols. 2). Minsk : «Belarus», 1, 495; 2, 463.
Pentiuk, N. O., Pentiuk, O. O. (2001). Liky, 5-6, 82–85.
Mamchur, V., Podpletniaia, Ye., Makarenko, O. (2005). Visnyk farmakolohii ta farmatsii, 4, 3–17.
Pentiuk, N. O. (2000). Liky, 6, 21–24.
Perazella, M. A. (2003). Drug-Induced Renal Failure: Update on New Medications and Unique Mechanisms of Nephrotoxicity. The American Journal of the Medical Sciences, 325(6), 349–362. https://doi.org/10.1097/00000441-200306000-00006
Shtrygol, S. Iu. (2005). Provizor, 2, 37–42.
Karateev, A. E., Nasonov, E. L., Yakhno, N. N., Ivashkin, V. T., Chichasova, N. V., Alekseeva, L. I., … Abuzarova, G. R. (2015). Clinical guidelines «Rational use of nonsteroidal anti-inflammatory drugs (NSAIDs) in clinical practice». Modern Rheumatology Journal, (1), 4. https://doi.org/10.14412/1996-7012-2015-1-4-23
Downloads
Published
Issue
Section
License
Copyright (c) 2020 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
